PMID- 15168030
OWN - NLM
STAT- MEDLINE
DCOM- 20050131
LR  - 20191210
IS  - 0009-4722 (Print)
IS  - 0009-4722 (Linking)
VI  - 75
IP  - 9
DP  - 2004 Sep
TI  - [Multiple endocrine neoplasia type 1. Surgical therapy of primary 
      hyperparathyroidism].
PG  - 900-6
AB  - Primary hyperparathyroidism (pHPT) occurs in about 90% of patients with multiple 
      endocrine neoplasia type 1 (MEN1). In contrast to sporadic pHPT, multiple gland 
      disease is most common in MEN1. The appropriate surgical approach is still 
      controversial. The aim of this study was to analyze the results of surgical 
      therapy of pHPT in patients with genetically confirmed MEN1. In an observational 
      study, preoperative data, operative procedures, long-term results, and a possible 
      genotype-phenotype correlation were analyzed in patients with pHPT and 
      genetically confirmed MEN1. According to our results, tPTX+T (total 
      parathyroidectomy+thymectomy+autotransplantation) seems to be a more favorable 
      surgical approach in patients with MEN1 pHPT than sDE (selective gland 
      exstirpation) and stPTX (subtotal parathyroidectromy) without cervical 
      thymectomy, because recurrences or persistence of the disease are rare. A 
      prospective randomized trial is needed to compare stPTX including cervical 
      thymectomy vs tPTX+T. A genotype-phenotype correlation could not be identified.
FAU - Langer, P
AU  - Langer P
AD  - Klinik fur Visceral-, Thorax- und Gefasschirurgie, Philipps-Universitat Marburg, 
      Baldingerstrasse, 35043 Marburg, Germany. langerp@mailer.uni-marburg.de
FAU - Wild, A
AU  - Wild A
FAU - Schilling, T
AU  - Schilling T
FAU - Nies, C
AU  - Nies C
FAU - Rothmund, M
AU  - Rothmund M
FAU - Bartsch, D K
AU  - Bartsch DK
LA  - ger
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
TT  - Multiple endokrine Neoplasie Typ 1. Chirurgische Therapie des primaren 
      Hyperparathyreoidismus.
PL  - Germany
TA  - Chirurg
JT  - Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen
JID - 16140410R
SB  - IM
MH  - Chi-Square Distribution
MH  - Follow-Up Studies
MH  - Genotype
MH  - Humans
MH  - Hyperparathyroidism/diagnosis/genetics/*surgery
MH  - Multiple Endocrine Neoplasia Type 1/diagnosis/genetics/*surgery
MH  - Mutation
MH  - *Parathyroidectomy
MH  - Phenotype
MH  - Reoperation
MH  - *Thymectomy
MH  - Time Factors
EDAT- 2004/05/29 05:00
MHDA- 2005/02/03 09:00
CRDT- 2004/05/29 05:00
PHST- 2004/05/29 05:00 [pubmed]
PHST- 2005/02/03 09:00 [medline]
PHST- 2004/05/29 05:00 [entrez]
AID - 10.1007/s00104-004-0838-4 [doi]
PST - ppublish
SO  - Chirurg. 2004 Sep;75(9):900-6. doi: 10.1007/s00104-004-0838-4.