PMID- 15170164
OWN - NLM
STAT- MEDLINE
DCOM- 20050307
LR  - 20040719
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 34
IP  - 3
DP  - 2004 Aug
TI  - Successful non-T-cell-depleted nonmyeloablative hematopoietic stem cell 
      transplantation (NST) from an HLA-haploidentical 2-loci-mismatched sibling in a 
      heavily transfused patient with severe aplastic anemia based on the fetomaternal 
      microchimerism.
PG  - 267-9
AB  - A 37-year-old Japanese man with systemic hemochromatosis due to multiple 
      transfusions was referred to us for the treatment of severe aplastic anemia 
      (SAA), from which he had been suffering for 24 years. The patient had diabetes 
      arising from the hemochromatosis, chronic anal fissures, and a kidney abscess due 
      to neutropenia. He was treated with a nonmyeloablative preconditioning regimen 
      followed by non-T-cell-depleted (non-TCD) allogeneic peripheral blood stem cell 
      transplantation (PBSCT) from his human leukocyte antigen (HLA)-haploidentical 
      2-loci-mismatched sibling. Prompt engraftment of granulocytes and platelets was 
      observed, and graft-versus-host disease was easy to control. Noninherited 
      maternal antigens in the donor were confirmed prior to PBSCT, and they were also 
      detected in small quantities in the recipient. This report describes the first 
      successful nonmyeloablative hematopoietic stem cell transplant in a heavily 
      transfused SAA patient from an HLA-haploidentical 2-loci-mismatched sibling 
      donor. The result suggests that a long-term fetomaternal microchimerism-positive 
      sibling can be a second-line donor if an alternative HLA-identical donor is not 
      available.
FAU - Tsutsumi, Y
AU  - Tsutsumi Y
AD  - Department of Internal Medicine, Hakodate Municipal Hospital, Hakodate, Japan. 
      rtsutsu@nyc.odn.ne.jp
FAU - Tanaka, J
AU  - Tanaka J
FAU - Miura, T
AU  - Miura T
FAU - Saitoh, S
AU  - Saitoh S
FAU - Yamada, M
AU  - Yamada M
FAU - Yamato, H
AU  - Yamato H
FAU - Ehira, N
AU  - Ehira N
FAU - Kanamori, H
AU  - Kanamori H
FAU - Kawamura, T
AU  - Kawamura T
FAU - Obara, S
AU  - Obara S
FAU - Ogura, N
AU  - Ogura N
FAU - Matsushima, T
AU  - Matsushima T
FAU - Maruya, E
AU  - Maruya E
FAU - Asaka, M
AU  - Asaka M
FAU - Imamura, M
AU  - Imamura M
FAU - Saji, H
AU  - Saji H
FAU - Masauzi, N
AU  - Masauzi N
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
SB  - IM
MH  - Adult
MH  - Anemia, Aplastic/complications/immunology/*therapy
MH  - Blood Transfusion
MH  - Haploidy
MH  - Histocompatibility Testing
MH  - Humans
MH  - *Lymphocyte Depletion
MH  - Male
MH  - Siblings
MH  - *Stem Cell Transplantation
MH  - T-Lymphocytes/*immunology
MH  - Transplantation, Homologous/immunology
MH  - Treatment Outcome
EDAT- 2004/06/01 05:00
MHDA- 2005/03/08 09:00
CRDT- 2004/06/01 05:00
PHST- 2004/06/01 05:00 [pubmed]
PHST- 2005/03/08 09:00 [medline]
PHST- 2004/06/01 05:00 [entrez]
AID - 1704567 [pii]
AID - 10.1038/sj.bmt.1704567 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2004 Aug;34(3):267-9. doi: 10.1038/sj.bmt.1704567.