PMID- 15170644
OWN - NLM
STAT- MEDLINE
DCOM- 20041221
LR  - 20081121
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 73
IP  - 3
DP  - 2004 Jul
TI  - Human herpesvirus 6 (HHV-6) is transmitted from parent to child in an integrated 
      form and characterization of cases with chromosomally integrated HHV-6 DNA.
PG  - 465-73
AB  - We obtained 7,566 peripheral blood mononuclear cell (PBMC) samples from 2,332 
      individuals and screened them for human herpesvirus infection. We identified five 
      individuals who persistently harbored high copy numbers of human herpesvirus 6 
      (HHV-6) DNA in their PBMCs. HHV-6 DNA was also detected in other somatic tissues 
      of these individuals. Five additional cases were identified among their family 
      members. For two of these families, chromosomally integrated HHV-6 DNA (CIHHV-6) 
      was detected in the PBMCs by fluorescence in situ hybridization. The prevalence 
      of CIHHV-6 among all the subjects was 0.21%. The HHV-6 DNA was variant B in four 
      families and variant A in one family. Antibodies to immediate early antigen and 
      glycoprotein B were detected in 57 and 14% of individuals with CIHHV-6 and in 0 
      and 60% of healthy volunteers without CIHHV-6, respectively. HHV-6 could not be 
      isolated from PBMCs with CIHHV-6. These cases shared no clinical features, and 
      included three healthy individuals. Our data suggest that CIHHV-6 is rare but 
      detectable in the general population and that hereditary transmission is one of 
      the routes of HHV-6 transmission.
CI  - Copyright 2004 Wiley-Liss, Inc.
FAU - Tanaka-Taya, Keiko
AU  - Tanaka-Taya K
AD  - Department of Developmental Medicine (Pediatrics), Osaka University Graduate 
      School of Medicine, Osaka, Japan. ktaya@nih.go.jp
FAU - Sashihara, Junji
AU  - Sashihara J
FAU - Kurahashi, Hiroki
AU  - Kurahashi H
FAU - Amo, Kiyoko
AU  - Amo K
FAU - Miyagawa, Hiromi
AU  - Miyagawa H
FAU - Kondo, Kazuhiro
AU  - Kondo K
FAU - Okada, Shintaro
AU  - Okada S
FAU - Yamanishi, Koichi
AU  - Yamanishi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
RN  - 0 (Immediate-Early Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (Viral Envelope Proteins)
RN  - 0 (immediate-early 1 protein, human herpesvirus 6)
RN  - 148770-71-2 (glycoprotein B, human herpesvirus-6)
SB  - IM
MH  - Antibodies, Viral/blood
MH  - Chromosomes, Human/virology
MH  - DNA, Viral/*analysis
MH  - Female
MH  - Hair/virology
MH  - Herpesvirus 6, Human/*genetics/isolation & purification
MH  - Humans
MH  - Immediate-Early Proteins/immunology
MH  - In Situ Hybridization, Fluorescence
MH  - *Infectious Disease Transmission, Vertical
MH  - Leukocytes, Mononuclear/*virology
MH  - Male
MH  - Mouth Mucosa/virology
MH  - Pedigree
MH  - Pharynx/virology
MH  - Phosphoproteins/immunology
MH  - Polymerase Chain Reaction
MH  - Roseolovirus Infections/*transmission/*virology
MH  - Viral Envelope Proteins/immunology
MH  - *Virus Integration
EDAT- 2004/06/02 05:00
MHDA- 2004/12/22 09:00
CRDT- 2004/06/02 05:00
PHST- 2004/06/02 05:00 [pubmed]
PHST- 2004/12/22 09:00 [medline]
PHST- 2004/06/02 05:00 [entrez]
AID - 10.1002/jmv.20113 [doi]
PST - ppublish
SO  - J Med Virol. 2004 Jul;73(3):465-73. doi: 10.1002/jmv.20113.