PMID- 15171213
OWN - NLM
STAT- MEDLINE
DCOM- 20040727
LR  - 20200928
IS  - 0446-6586 (Print)
IS  - 0446-6586 (Linking)
VI  - 101
IP  - 5
DP  - 2004 May
TI  - [Strategy for bacterial translocation in acute pancreatitis].
PG  - 502-9
AB  - Although bacterial translocation (BT) is thought to be a main cause of secondary 
      pancreatic infection, the clinical significance is still unclear. Therefore, we 
      investigated relationship between pancreatic infection and BT, analyzing the 
      results of treatments such as continuous regional arterial infusion of protease 
      inhibitor and antibiotics (CRAI), selective digestive decontamination, and early 
      enteral nutrition (SDD/EN) in 45 severe acute pancreatitis patients. The 
      infection rate of 17 cases without CRAI, SDD/EN was 58.8%, and mortality was 
      23.5%. Antibiotics-resistant bacteria, such as methicillin-resistant 
      Staphylococcus aureus (MRSA) was often proven in infected pancreatic tissue. 
      Whereas, in 16 cases who underwent both therapy, only one patient died of 
      multi-organ failure (6.3%). Pseudomonas aeruginosa and K. pneumoniae were proven 
      from his feces before pancreatic infection coincidence, and, in autopsy, these 
      bacteria and MRSA were proved from necrotic pancreatic tissue. BT must be large 
      cause of secondary pancreas infection, because CRAI and SDD/ EN prevent secondary 
      pancreatic infection. But we must consider other infection routes, and 
      development of antibiotics resistant bacteria.
FAU - Furuya, Tomoki
AU  - Furuya T
AD  - Department of Surgery, Akita City Hospital.
FAU - Soeno, Takehiko
AU  - Soeno T
FAU - Komatsu, Masafumi
AU  - Komatsu M
LA  - jpn
PT  - Journal Article
PL  - Japan
TA  - Nihon Shokakibyo Gakkai Zasshi
JT  - Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology
JID - 2984683R
RN  - 0 (Drug Combinations)
RN  - 0 (Protease Inhibitors)
RN  - 141A6AMN38 (Cilastatin)
RN  - 71OTZ9ZE0A (Imipenem)
RN  - 92309-29-0 (Cilastatin, Imipenem Drug Combination)
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - *Bacterial Translocation
MH  - Cilastatin/administration & dosage
MH  - Cilastatin, Imipenem Drug Combination
MH  - Decontamination/methods
MH  - Digestive System/microbiology
MH  - Drug Combinations
MH  - Enteral Nutrition
MH  - Female
MH  - Humans
MH  - Imipenem/administration & dosage
MH  - Infusions, Intra-Arterial
MH  - Male
MH  - Middle Aged
MH  - Pancreatitis/*microbiology/prevention & control/*therapy
MH  - Protease Inhibitors/administration & dosage
MH  - *Pseudomonas Infections
MH  - *Staphylococcal Infections
EDAT- 2004/06/03 05:00
MHDA- 2004/07/28 05:00
CRDT- 2004/06/03 05:00
PHST- 2004/06/03 05:00 [pubmed]
PHST- 2004/07/28 05:00 [medline]
PHST- 2004/06/03 05:00 [entrez]
PST - ppublish
SO  - Nihon Shokakibyo Gakkai Zasshi. 2004 May;101(5):502-9.