PMID- 15171453
OWN - NLM
STAT- MEDLINE
DCOM- 20040730
LR  - 20191210
IS  - 0022-7854 (Print)
IS  - 0022-7854 (Linking)
VI  - 41
IP  - 1
DP  - 2004 Feb
TI  - [Usefulness of 201Tl SPECT in the predication of mediastinal lymph nodes 
      metastasis in patients with non small cell lung carcinoma (NSCLC)].
PG  - 1-7
AB  - Predictivity of mediastinal lymph nodes metastasis of 201Tl SPECT were examined 
      before operation in 113 patients with non-small cell lung cancer (69 
      adenocarcinoma, 31 squamous cell carcinoma, 10 large cell carcinoma, 2 
      bronchiolo-alveolar carcinoma, 1 neuroendocrine cell carcinoma). Patients were 
      classified into two groups, with or without lymph nodes metastasis according to 
      the pathological diagnosis. We calculated parameters of 201Tl SPECT early ratio, 
      delayed ratio, retention index (RI) and maximal diameters. In addition, we 
      calculated optimal cut-off value of RI to estimate the mediastinal lymph nodes 
      metastasis. Mediastinal lymph nodes metastasis was confirmed pathologically in 62 
      patients. ER and DR did not show any statistical significance between two groups. 
      Maximal diameters of primary tumor were also comparable between two groups. RI 
      was significantly higher in mediastinal lymph node metastasis positive group 
      compared to that in mediastinal lymph node metastasis negative group. The 
      sensitivity (Sen), specificity (Spe), positive predictive value (PPV), negative 
      predictive value (NPV) and accuracy (Acc) of 201Tl SPECT were 82.2%, 82.3%, 
      85.0%, 79.2% and 82.3%. These parameters were similar of higher than 72.6%, 
      82.4%, 83.3%, 71.2% and 77.0% of chest CT. The RI of 201Tl SPECT was useful tool 
      for predicting lymph nodes metastasis in non-small cell lung cancer. The optimum 
      cut-off value of RI in the prediction of mediastinal lymph nodes metastasis was 
      35%. We should take into account of upstaging in cases with higher RI (>35%).
FAU - Fujita, Seigo
AU  - Fujita S
AD  - Department of Radiology, Miyazaki Medical College. Iamfine@fc.miyazaki-med.ac.jp
FAU - Nagamachi, Shigeki
AU  - Nagamachi S
FAU - Nishii, Ryuichi
AU  - Nishii R
FAU - Futami, Shigemi
AU  - Futami S
FAU - Nakada, Hiroshi
AU  - Nakada H
FAU - Kuroki, Masaomi
AU  - Kuroki M
FAU - Ono, Seiji
AU  - Ono S
FAU - Tamura, Shozo
AU  - Tamura S
FAU - Matsuzaki, Yasunori
AU  - Matsuzaki Y
FAU - Onizuka, Toshio
AU  - Onizuka T
FAU - Asada, Yujiro
AU  - Asada Y
FAU - Kataoka, Hiroaki
AU  - Kataoka H
LA  - jpn
PT  - Evaluation Study
PT  - Journal Article
PL  - Japan
TA  - Kaku Igaku
JT  - Kaku igaku. The Japanese journal of nuclear medicine
JID - 2985202R
RN  - 0 (Radiopharmaceuticals)
RN  - 37CB58V15B (thallium chloride)
RN  - AD84R52XLF (Thallium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Non-Small-Cell Lung/*diagnostic imaging/secondary
MH  - Female
MH  - Humans
MH  - Lung Neoplasms/*pathology
MH  - Lymphatic Metastasis/diagnostic imaging
MH  - Male
MH  - Mediastinum
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - *Radiopharmaceuticals
MH  - *Thallium
MH  - *Tomography, Emission-Computed, Single-Photon
EDAT- 2004/06/03 05:00
MHDA- 2004/07/31 05:00
CRDT- 2004/06/03 05:00
PHST- 2004/06/03 05:00 [pubmed]
PHST- 2004/07/31 05:00 [medline]
PHST- 2004/06/03 05:00 [entrez]
PST - ppublish
SO  - Kaku Igaku. 2004 Feb;41(1):1-7.