PMID- 15174779
OWN - NLM
STAT- MEDLINE
DCOM- 20041021
LR  - 20190823
IS  - 0803-5253 (Print)
IS  - 0803-5253 (Linking)
VI  - 93
IP  - 5
DP  - 2004 May
TI  - Zinc supplementation for four months does not affect plasma copper concentration 
      in infants.
PG  - 599-602
AB  - AIM: The aim of the present study, which was undertaken as a sub-study within a 
      randomized controlled trial of zinc supplementation, was to evaluate the effect 
      of prolonged zinc supplementation on copper status as assessed by hematological 
      markers. METHODS: Plasma copper and zinc were estimated at baseline and after 120 
      d of supplementation in a randomly selected infant subset (115) of the children. 
      Of these, 61 children were in a zinc group (Z) getting 10 mg of elemental zinc, 
      and 54 were in a control group (C) getting supplement without zinc. RESULTS: 
      Baseline plasma zinc was comparable in the two groups; post-supplementation zinc 
      was significantly higher (Z 93.0 +/- 3.6 vs C 60.6 +/- 8.0) in the zinc 
      supplementation group. There was no significant difference in the mean/median 
      copper levels between the zinc and control groups. The percentage of children 
      with plasma copper <100 microg/dl was also not significantly different between 
      groups (baseline Z 14.8%, C 11.1%; post-supplementation Z 18.0%, C 11.1%). There 
      were no differences between the zinc and control groups after 120 d of 
      supplementation in hemoglobin (Hgb), mean corpuscular volume (MCV), mean 
      corpuscular hemoglobin concentration (MCHC), or number of lymphocytes or 
      granulocytes. CONCLUSION: Zinc supplementation of 10 mg/d for 4 mo in this study 
      did not affect copper status, as assessed by plasma copper concentration and 
      hematological parameters, diagnostics of copper deficiency.
FAU - Sazawal, S
AU  - Sazawal S
AD  - Department of International Health, Johns Hopkins Bloomberg School of Public 
      Health, Baltimore, MD, USA. ssazawal@jhsph.edu
FAU - Malik, P
AU  - Malik P
FAU - Jalla, S
AU  - Jalla S
FAU - Krebs, N
AU  - Krebs N
FAU - Bhan, M K
AU  - Bhan MK
FAU - Black, R E
AU  - Black RE
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Norway
TA  - Acta Paediatr
JT  - Acta paediatrica (Oslo, Norway : 1992)
JID - 9205968
RN  - 0 (Hemoglobins)
RN  - 789U1901C5 (Copper)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Copper/*blood
MH  - *Dietary Supplements
MH  - Female
MH  - Hemoglobins/analysis
MH  - Humans
MH  - Infant
MH  - Male
MH  - Time Factors
MH  - Zinc/*administration & dosage/blood
EDAT- 2004/06/04 05:00
MHDA- 2004/10/22 09:00
CRDT- 2004/06/04 05:00
PHST- 2004/06/04 05:00 [pubmed]
PHST- 2004/10/22 09:00 [medline]
PHST- 2004/06/04 05:00 [entrez]
AID - 10.1111/j.1651-2227.2004.tb18254.x [doi]
PST - ppublish
SO  - Acta Paediatr. 2004 May;93(5):599-602. doi: 10.1111/j.1651-2227.2004.tb18254.x.