PMID- 15175385
OWN - NLM
STAT- MEDLINE
DCOM- 20040709
LR  - 20200225
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 24
IP  - 22
DP  - 2004 Jun 2
TI  - Dopamine modulates use-dependent plasticity of inhibitory synapses.
PG  - 5162-71
AB  - The release of the hormones oxytocin (OT) and vasopressin (VP) into the 
      circulation is dictated by the electrical activity of hypothalamic magnocellular 
      neurosecretory cells (MNCs). In the paraventricular nucleus of the hypothalamus 
      (PVN), MNC neuronal activity is exquisitely sensitive to changes in input from 
      inhibitory GABAergic synapses. To explore the hypothesis that efficacy at these 
      synapses is dictated by the rate at which a given synapse is activated, we 
      obtained whole-cell recordings from MNCs in postnatal day 21-27 male Sprague 
      Dawley rat brain slices. IPSCs were elicited by electrically stimulating 
      GABAergic projections from either the suprachiasmatic nucleus or putative 
      interneuron populations immediately ventral to the fornix at 5, 10, 20, and 50 
      Hz. Short-term plasticity was observed at 88% of the synapses tested. Of this 
      group, synaptic depression was observed in 58%, and synaptic facilitation was 
      observed in 41%. Identification of cells using a combined electrophysiological 
      and immunohistochemical approach revealed a strong correlation between cell 
      phenotype and the nature of the plasticity. Short-term facilitation was observed 
      preferentially in OT cells (86%), whereas short-term depression was predominant 
      in VP neurons (69%). We next examined the effects of dopamine, which increases 
      MNC excitability, on short-term plasticity. Activation of presynaptic D(4) 
      receptors decreased the frequency of miniature IPSCs and prevented the 
      development of synaptic depression at higher rates of activity. Synaptic 
      facilitation, however, was unaffected by dopamine. These findings demonstrate 
      that, by lowering GABA release probability, dopamine confers high-pass filtering 
      properties to the majority of inhibitory synapses onto MNCs in PVN.
FAU - Baimoukhametova, Dinara V
AU  - Baimoukhametova DV
AD  - Neuroscience Research Group, Department of Physiology and Biophysics, University 
      of Calgary, Calgary, Alberta, Canada T2N 4N1.
FAU - Hewitt, Sarah A
AU  - Hewitt SA
FAU - Sank, Cheryl A
AU  - Sank CA
FAU - Bains, Jaideep S
AU  - Bains JS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Drd4 protein, rat)
RN  - 0 (Receptors, Dopamine D2)
RN  - 137750-34-6 (Receptors, Dopamine D4)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Action Potentials/drug effects/physiology
MH  - Animals
MH  - Dopamine/pharmacology/*physiology
MH  - Electric Stimulation/methods
MH  - Hypothalamus/physiology
MH  - In Vitro Techniques
MH  - Interneurons/physiology
MH  - Male
MH  - Neural Inhibition/drug effects/physiology
MH  - Neuronal Plasticity/drug effects/*physiology
MH  - Neurons/drug effects/physiology
MH  - Neurosecretory Systems/cytology/physiology
MH  - Paraventricular Hypothalamic Nucleus/physiology
MH  - Patch-Clamp Techniques
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Dopamine D2/drug effects/metabolism
MH  - Receptors, Dopamine D4
MH  - Suprachiasmatic Nucleus/physiology
MH  - Synapses/drug effects/*physiology
MH  - gamma-Aminobutyric Acid/metabolism
PMC - PMC6729188
EDAT- 2004/06/04 05:00
MHDA- 2004/07/10 05:00
PMCR- 2004/12/02
CRDT- 2004/06/04 05:00
PHST- 2004/06/04 05:00 [pubmed]
PHST- 2004/07/10 05:00 [medline]
PHST- 2004/06/04 05:00 [entrez]
PHST- 2004/12/02 00:00 [pmc-release]
AID - 24/22/5162 [pii]
AID - 10.1523/JNEUROSCI.4979-03.2004 [doi]
PST - ppublish
SO  - J Neurosci. 2004 Jun 2;24(22):5162-71. doi: 10.1523/JNEUROSCI.4979-03.2004.