PMID- 15177939
OWN - NLM
STAT- MEDLINE
DCOM- 20050111
LR  - 20191210
IS  - 0167-0115 (Print)
IS  - 0167-0115 (Linking)
VI  - 120
IP  - 1-3
DP  - 2004 Aug 15
TI  - Central NPY receptor-mediated alteration of heart rate dynamics in mice during 
      expression of fear conditioned to an auditory cue.
PG  - 205-14
AB  - Neuropeptide Y (NPY) is involved in the regulation of emotionality including fear 
      and anxiety, which modulate autonomic control of cardiovascular function. We 
      therefore investigated the central effects of porcine NPY, selective Y1, Y2 and 
      Y5 receptor agonists and a Y1 receptor antagonist on heart rate (HR) and HR 
      variability in freely moving mice using auditory fear conditioning. 
      Intracerebroventricular (i.c.v.) injections were applied 15 min before the 
      tone-dependent memory test. NPY dose-dependently induced bradycardia associated 
      with decreased HR variability, and blunted the stress-induced tachycardic 
      response. The selective Y1 receptor antagonist BIBO 3304 blocked the NPY- and 
      Y1-receptor agonist-induced suppression of conditioned tachycardia without 
      affecting basal HR. The tachycardia elicited by both conditioned and 
      unconditioned stressor was effectively attenuated by the Y1 receptor agonist. 
      These results suggest a specific contribution of Y1, but not Y2 and Y5 receptors, 
      to modulation of emotional responses most likely unrelated to impairment or 
      modulation of memory. The NPY-induced bradycardia is attributed to not yet 
      characterized NPY receptor subtypes other than Y1, Y2 and Y5, or a complex 
      receptor interaction. In conclusion, NPY mediates central inhibition of 
      sympathetic outflow, potentially coupled with attenuation of parasympathetic 
      tone, i.e., mechanisms that may be associated with the reported anxiolytic 
      action.
FAU - Tovote, Philip
AU  - Tovote P
AD  - Department of Molecular Neuroendocrinology, Max Planck Institute for Experimental 
      Medicine, Gottingen, Germany.
FAU - Meyer, Michael
AU  - Meyer M
FAU - Beck-Sickinger, Annette G
AU  - Beck-Sickinger AG
FAU - von Horsten, Stephan
AU  - von Horsten S
FAU - Ove Ogren, Sven
AU  - Ove Ogren S
FAU - Spiess, Joachim
AU  - Spiess J
FAU - Stiedl, Oliver
AU  - Stiedl O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Regul Pept
JT  - Regulatory peptides
JID - 8100479
RN  - 0 (Neuropeptide Y)
RN  - 0 (Receptors, Neuropeptide Y)
RN  - 94ZLA3W45F (Arginine)
RN  - O35HK034KO (BIBO 3304)
SB  - IM
MH  - Animals
MH  - Arginine/*analogs & derivatives/pharmacology
MH  - Auditory Perception/*physiology
MH  - Bradycardia/metabolism/pathology
MH  - Conditioning, Psychological
MH  - Cues
MH  - Fear/*physiology
MH  - Heart Rate/*drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Neuropeptide Y/*pharmacology
MH  - *Receptors, Neuropeptide Y/agonists/antagonists & inhibitors/metabolism
MH  - Swine
EDAT- 2004/06/05 05:00
MHDA- 2005/01/12 09:00
CRDT- 2004/06/05 05:00
PHST- 2003/11/27 00:00 [received]
PHST- 2004/03/05 00:00 [revised]
PHST- 2004/03/15 00:00 [accepted]
PHST- 2004/06/05 05:00 [pubmed]
PHST- 2005/01/12 09:00 [medline]
PHST- 2004/06/05 05:00 [entrez]
AID - S0167011504000849 [pii]
AID - 10.1016/j.regpep.2004.03.011 [doi]
PST - ppublish
SO  - Regul Pept. 2004 Aug 15;120(1-3):205-14. doi: 10.1016/j.regpep.2004.03.011.