PMID- 15178024
OWN - NLM
STAT- MEDLINE
DCOM- 20040830
LR  - 20061115
IS  - 0141-1136 (Print)
IS  - 0141-1136 (Linking)
VI  - 58
IP  - 2-5
DP  - 2004 Aug-Dec
TI  - Cloning of cytochrome P450 1A (CYP1A) genes from the hermaphrodite fish Rivulus 
      marmoratus and the Japanese medaka Oryzias latipes.
PG  - 125-9
AB  - To use two small fish Rivulus marmoratus (Cyprinodontiformes, Rivulidae) and the 
      Japanese medaka Oryzias latipes (Belloniformes) as testing models in molecular 
      ecotoxicology, we have cloned the cytochrome P450 1A (CYP1A) gene after screening 
      of both genomic DNA libraries, and sequenced 11,863 and 7,243 bp including all 
      the exons and introns with promoter regions, respectively. The Rivulus and the 
      medaka CYP1A gene consisted of seven exons (including non-coding exons) with high 
      homology to mammals. In the promoter region, Rivulus CYP1A gene has seven 
      xenobiotic response elements (XREs) and two metal response elements (MREs), while 
      the Japanese medaka CYP1A gene has six XREs and four MREs. Interestingly, medaka 
      CYP1A gene has a number of MREs at the promoter, which may affect its response on 
      metal exposure. We describe here the gene structure of both fish CYP1A genes.
FAU - Kim, Il-Chan
AU  - Kim IC
AD  - Department of Biochemistry, College of Medicine, Hanyang University, Seoul 
      133-791, Republic of Korea.
FAU - Kim, Young Ja
AU  - Kim YJ
FAU - Yoon, Yong-Dal
AU  - Yoon YD
FAU - Kawamura, Shoji
AU  - Kawamura S
FAU - Lee, Yong-Sung
AU  - Lee YS
FAU - Lee, Jae-Seong
AU  - Lee JS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Mar Environ Res
JT  - Marine environmental research
JID - 9882895
RN  - 0 (Xenobiotics)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Cloning, Molecular
MH  - Cluster Analysis
MH  - Cyprinodontiformes/*genetics
MH  - Cytochrome P-450 CYP1A1/*genetics
MH  - Gene Components
MH  - Molecular Sequence Data
MH  - Oryzias/*genetics
MH  - *Phylogeny
MH  - Response Elements/genetics
MH  - Sequence Analysis, DNA
MH  - Sequence Homology
MH  - Xenobiotics
EDAT- 2004/06/05 05:00
MHDA- 2004/08/31 05:00
CRDT- 2004/06/05 05:00
PHST- 2004/06/05 05:00 [pubmed]
PHST- 2004/08/31 05:00 [medline]
PHST- 2004/06/05 05:00 [entrez]
AID - S0141-1136(04)00038-8 [pii]
AID - 10.1016/j.marenvres.2004.03.006 [doi]
PST - ppublish
SO  - Mar Environ Res. 2004 Aug-Dec;58(2-5):125-9. doi: 
      10.1016/j.marenvres.2004.03.006.