PMID- 15178886
OWN - NLM
STAT- MEDLINE
DCOM- 20040802
LR  - 20061115
IS  - 1018-2438 (Print)
IS  - 1018-2438 (Linking)
VI  - 134
IP  - 3
DP  - 2004 Jul
TI  - The regulatory role of dendritic cells in the immune response.
PG  - 179-85
AB  - Dendritic cells (DCs) are key regulators of immune reactions. They control early 
      innate responses, regulate long-lasting adaptive immunity and contribute to the 
      maintenance of self-tolerance. DCs continuously monitor the environment through a 
      multifaceted innate antigen receptor repertoire and, in response to 
      perturbations, start a complex genetic reprogramming that leads to a complete 
      activation of innate and, then, adaptive immune responses. This review discusses 
      how DCs become efficient activators of NK and, subsequently, T cells following a 
      microbial encounter.
CI  - Copyright 2004 S. Karger AG, Basel
FAU - Granucci, Francesca
AU  - Granucci F
AD  - Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milano, 
      Italy.
FAU - Zanoni, Ivan
AU  - Zanoni I
FAU - Feau, Sonia
AU  - Feau S
FAU - Capuano, Giusy
AU  - Capuano G
FAU - Ricciardi-Castagnoli, Paola
AU  - Ricciardi-Castagnoli P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20040601
PL  - Switzerland
TA  - Int Arch Allergy Immunol
JT  - International archives of allergy and immunology
JID - 9211652
RN  - 0 (Interleukin-2)
SB  - IM
MH  - Animals
MH  - Cell Differentiation
MH  - Dendritic Cells/*immunology/metabolism
MH  - Humans
MH  - Interleukin-2/biosynthesis
MH  - Killer Cells, Natural/immunology
MH  - Lymphocyte Activation
MH  - Signal Transduction/*immunology
MH  - T-Lymphocytes/immunology
RF  - 57
EDAT- 2004/06/05 05:00
MHDA- 2004/08/03 05:00
CRDT- 2004/06/05 05:00
PHST- 2004/06/05 05:00 [pubmed]
PHST- 2004/08/03 05:00 [medline]
PHST- 2004/06/05 05:00 [entrez]
AID - 78764 [pii]
AID - 10.1159/000078764 [doi]
PST - ppublish
SO  - Int Arch Allergy Immunol. 2004 Jul;134(3):179-85. doi: 10.1159/000078764. Epub 
      2004 Jun 1.