PMID- 15179560
OWN - NLM
STAT- MEDLINE
DCOM- 20040824
LR  - 20201208
IS  - 1434-5161 (Print)
IS  - 1434-5161 (Linking)
VI  - 49
IP  - 7
DP  - 2004
TI  - Association between genetic variation in the gene for death-associated protein-3 
      (DAP3) and adult asthma.
PG  - 370-375
LID - 10.1007/s10038-004-0161-4 [doi]
AB  - Lung epithelium plays a central role in modulation of the lung inflammatory 
      response, and lung repair and airway epithelial cells are targets in asthma and 
      viral infection. Activated T lymphocytes release cytokines such as 
      interferon-gamma (IFN-gamma) that induce apoptosis, or programmed cell death, of 
      damaged epithelial cells. Death-associated protein-3 (DAP3) is involved in 
      mediating IFN-gamma-induced cell death. To assess the possible involvement of 
      genetic variants of DAP3 with asthma, we searched for single-nucleotide 
      polymorphisms (SNPs) in the gene and conducted a case-control study with 1,341 
      subjects. We found a strong association between bronchial asthma (BA) in adults 
      (P=0.0051, odds ratio=1.87, 95% CI=1.20-2.92), whereas no association was found 
      with childhood asthma. The tendency was more prominent in patients with higher 
      serum total immunoglobulin E (IgE) (>250 IU/ml) (P=0.00061, odds ratio=2.40, 95% 
      CI=1.44-4.00). DAP3 was expressed in normal bronchial epithelial cells, and the 
      expression was induced by IFN-gamma. These results indicated that specific 
      variants of the DAP3 gene might be associated with the mechanisms responsible for 
      adult BA and contribute to airway inflammation and remodeling.
FAU - Hirota, Tomomitsu
AU  - Hirota T
AD  - Laboratory for Genetics of Allergic Diseases, SNP Research Center, The Institute 
      of Physical and Chemical Research (RIKEN), Kanagawa 230-0045, Japan.
AD  - Department of Microbiology and Immunology, Kagoshima University Dental School, 
      Kagoshima, Japan.
FAU - Obara, Kazuhiko
AU  - Obara K
AD  - Laboratory for Genetics of Allergic Diseases, SNP Research Center, The Institute 
      of Physical and Chemical Research (RIKEN), Kanagawa 230-0045, Japan.
FAU - Matsuda, Akira
AU  - Matsuda A
AD  - Laboratory for Genetics of Allergic Diseases, SNP Research Center, The Institute 
      of Physical and Chemical Research (RIKEN), Kanagawa 230-0045, Japan.
FAU - Akahoshi, Mitsuteru
AU  - Akahoshi M
AD  - Laboratory for Genetics of Allergic Diseases, SNP Research Center, The Institute 
      of Physical and Chemical Research (RIKEN), Kanagawa 230-0045, Japan.
FAU - Nakashima, Kazuko
AU  - Nakashima K
AD  - Department of Health Promotion and Human Behavior, Kyoto University Graduate 
      School of Public Health, Kyoto, Japan.
FAU - Hasegawa, Koichi
AU  - Hasegawa K
AD  - Department of Health Promotion and Human Behavior, Kyoto University Graduate 
      School of Public Health, Kyoto, Japan.
FAU - Takahashi, Naomi
AU  - Takahashi N
AD  - Laboratory for Genetics of Allergic Diseases, SNP Research Center, The Institute 
      of Physical and Chemical Research (RIKEN), Kanagawa 230-0045, Japan.
FAU - Shimizu, Makiko
AU  - Shimizu M
AD  - Laboratory for Genetics of Allergic Diseases, SNP Research Center, The Institute 
      of Physical and Chemical Research (RIKEN), Kanagawa 230-0045, Japan.
FAU - Sekiguchi, Hiroshi
AU  - Sekiguchi H
AD  - Laboratory for Genetics of Allergic Diseases, SNP Research Center, The Institute 
      of Physical and Chemical Research (RIKEN), Kanagawa 230-0045, Japan.
FAU - Kokubo, Miki
AU  - Kokubo M
AD  - Laboratory for Genetics of Allergic Diseases, SNP Research Center, The Institute 
      of Physical and Chemical Research (RIKEN), Kanagawa 230-0045, Japan.
FAU - Doi, Satoru
AU  - Doi S
AD  - Osaka Prefectural Habikino Hospital, Osaka, Japan.
FAU - Fujiwara, Hiroshi
AU  - Fujiwara H
AD  - Osaka Prefectural Habikino Hospital, Osaka, Japan.
FAU - Miyatake, Akihiko
AU  - Miyatake A
AD  - Miyatake Asthma Clinic, Osaka, Japan.
FAU - Fujita, Kimie
AU  - Fujita K
AD  - College of Nursing, University of Shiga, Shiga, Japan.
FAU - Enomoto, Tadao
AU  - Enomoto T
AD  - Wakayama Medical Center, Japanese Red Cross Society, Wakayama, Japan.
FAU - Kishi, Fumio
AU  - Kishi F
AD  - Department of Microbiology and Immunology, Kagoshima University Dental School, 
      Kagoshima, Japan.
FAU - Suzuki, Yoichi
AU  - Suzuki Y
AD  - Department of Medical Genetics, Tohoku University School of Medicine, Sendai, 
      Japan.
FAU - Saito, Hirohisa
AU  - Saito H
AD  - Department of Allergy and Immunology, National Research Institute for Child 
      Health and Development, Tokyo, Japan.
FAU - Nakamura, Yusuke
AU  - Nakamura Y
AD  - Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical 
      Science, The University of Tokyo, Tokyo, Japan.
FAU - Shirakawa, Taro
AU  - Shirakawa T
AD  - Laboratory for Genetics of Allergic Diseases, SNP Research Center, The Institute 
      of Physical and Chemical Research (RIKEN), Kanagawa 230-0045, Japan.
AD  - Department of Health Promotion and Human Behavior, Kyoto University Graduate 
      School of Public Health, Kyoto, Japan.
FAU - Tamari, Mayumi
AU  - Tamari M
AD  - Laboratory for Genetics of Allergic Diseases, SNP Research Center, The Institute 
      of Physical and Chemical Research (RIKEN), Kanagawa 230-0045, Japan. 
      tamari@src.riken.go.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040604
PL  - England
TA  - J Hum Genet
JT  - Journal of human genetics
JID - 9808008
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (DAP3 protein, human)
RN  - 0 (Proteins)
RN  - 0 (RNA-Binding Proteins)
RN  - 0 (Ribosomal Proteins)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Apoptosis
MH  - Apoptosis Regulatory Proteins
MH  - Asthma/*genetics
MH  - Case-Control Studies
MH  - Cell Death
MH  - Child
MH  - Child, Preschool
MH  - Epithelial Cells/metabolism
MH  - Female
MH  - Gene Frequency
MH  - *Genetic Variation
MH  - Genotype
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Interferon-gamma/metabolism
MH  - Lung/pathology
MH  - Male
MH  - Middle Aged
MH  - Models, Genetic
MH  - Odds Ratio
MH  - Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Proteins/*genetics
MH  - RNA-Binding Proteins
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Ribosomal Proteins
MH  - T-Lymphocytes/metabolism
MH  - Tissue Distribution
EDAT- 2004/06/05 05:00
MHDA- 2004/08/25 05:00
CRDT- 2004/06/05 05:00
PHST- 2004/01/19 00:00 [received]
PHST- 2004/04/15 00:00 [accepted]
PHST- 2004/06/05 05:00 [pubmed]
PHST- 2004/08/25 05:00 [medline]
PHST- 2004/06/05 05:00 [entrez]
AID - 10.1007/s10038-004-0161-4 [pii]
AID - 10.1007/s10038-004-0161-4 [doi]
PST - ppublish
SO  - J Hum Genet. 2004;49(7):370-375. doi: 10.1007/s10038-004-0161-4. Epub 2004 Jun 4.