PMID- 15180561
OWN - NLM
STAT- MEDLINE
DCOM- 20040713
LR  - 20190823
IS  - 0929-8673 (Print)
IS  - 0929-8673 (Linking)
VI  - 11
IP  - 12
DP  - 2004 Jun
TI  - Retinoids and receptor interacting protein 140 (RIP140) in gene regulation.
PG  - 1527-32
AB  - Retinoids exert pleiotropic effects in various biological processes by binding to 
      their nuclear receptors, the retinoic acid receptors (RARs) and retinoid X 
      receptors (RXRs), to regulate gene transcription. Apo-RARs and RXRs repress 
      target gene expression by recruiting corepressors to the target DNA, triggering 
      chromatin condensation by the action of histone deacetylases present in the 
      corepressor complexes. In contrast, holo-RARs and RXRs recruit coactivators, some 
      known to encode histone acetyl transferases, which trigger histone 
      hyperacetylation, chromatin decondensation, and ultimately gene activation. 
      Receptor interacting protein 140 (RIP140) represents a novel RAR/RXR coregulator 
      that suppresses vitamin A-regulated gene expression in a retinoid- dependent 
      manner. This review addresses the action of different retinoid ligands on gene 
      expression, the molecular mechanisms underlying RAR/RXR-mediated gene regulation, 
      and the unique properties of RIP140 as a novel retinoid hormone-dependent 
      negative coregulator for RAR- and RXR-mediated gene regulation.
FAU - Wei, Li-Na
AU  - Wei LN
AD  - Department of Pharmacology, University of Minnesota Medical School, 6-120 Jackson 
      Hall, 321 Church St. SE, Minneapolis, MN 55455, USA. weixx009@tc.umn.edu
LA  - eng
GR  - DA11190/DA/NIDA NIH HHS/United States
GR  - DA11806/DA/NIDA NIH HHS/United States
GR  - DK54733/DK/NIDDK NIH HHS/United States
GR  - DK60521/DK/NIDDK NIH HHS/United States
GR  - K02 DA13926/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United Arab Emirates
TA  - Curr Med Chem
JT  - Current medicinal chemistry
JID - 9440157
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Ligands)
RN  - 0 (NRIP1 protein, human)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Nuclear Receptor Interacting Protein 1)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Retinoid X Receptors)
RN  - 0 (Retinoids)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Animals
MH  - Gene Expression Regulation
MH  - Humans
MH  - Ligands
MH  - Nuclear Proteins/*physiology
MH  - Nuclear Receptor Interacting Protein 1
MH  - Receptors, Retinoic Acid/physiology
MH  - Retinoid X Receptors
MH  - Retinoids/metabolism/*physiology
MH  - Transcription Factors/physiology
MH  - Transcription, Genetic
MH  - Transcriptional Activation
RF  - 108
EDAT- 2004/06/08 05:00
MHDA- 2004/07/14 05:00
CRDT- 2004/06/08 05:00
PHST- 2004/06/08 05:00 [pubmed]
PHST- 2004/07/14 05:00 [medline]
PHST- 2004/06/08 05:00 [entrez]
AID - 10.2174/0929867043365017 [doi]
PST - ppublish
SO  - Curr Med Chem. 2004 Jun;11(12):1527-32. doi: 10.2174/0929867043365017.