PMID- 15181192
OWN - NLM
STAT- MEDLINE
DCOM- 20050715
LR  - 20061115
IS  - 0031-3998 (Print)
IS  - 0031-3998 (Linking)
VI  - 56
IP  - 2
DP  - 2004 Aug
TI  - Immune responses to strenuous exercise and carbohydrate intake in boys and men.
PG  - 227-34
AB  - Few studies describe immune responses to exercise in children, compared with 
      adults, and none have investigated the influence of carbohydrate (CHO) intake. We 
      hypothesized less perturbation and a faster recovery of the immune system with 
      exercise in children, regardless of supplemental energy. Twelve boys (9.8 +/- 0.1 
      y) and 10 men (22.1 +/- 0.5 y) cycled for 60 min at 70% o(2max) while drinking 6% 
      CHO (CHO-T) or flavored water (FW-T). Blood samples were collected before (PRE), 
      immediately after (POST), and 60 min after (REC) exercise. Boys, compared with 
      men, had smaller (p < 0.05) increases in total leukocytes (28% versus 38%), 
      natural killer (NK) cells (78% versus 236%), and NK T cells (42% versus 128%) at 
      POST, averaged across beverage trials. Exercise did not increase tumor necrosis 
      factor-alpha (TNF-alpha), but significantly (p < 0.05) increased IL-6 in men 
      (189%), but not in boys (11%). In both trials, lymphocytes and T cells at REC 
      were suppressed (p < 0.05), relative to PRE, in men (-21%), but not in boys (4%). 
      IL-6 remained elevated ( p< 0.001) in men at REC, with no change from POST in 
      boys. In boys, but not in men, CHO significantly (p < 0.05) attenuated increases 
      in neutrophil, lymphocyte, and NK cell counts at POST. Neutrophils at REC in 
      CHO-T were lower (p < 0.05) than in FW-T in men ( approximately 25%) and in boys 
      ( approximately 17%). CHO had no effect on TNF-alpha or IL-6 in either group. Our 
      results indicate a distinct pattern of the immune response to exercise and CHO 
      intake in boys, compared with men.
FAU - Timmons, Brian W
AU  - Timmons BW
AD  - Children's Exercise and Nutrition Centre, Chedoke Hospital, Evel Bldg. (4 floor), 
      Sanatorium Road, Hamilton, Ontario, Canada L8N 3Z5.
FAU - Tarnopolsky, Mark A
AU  - Tarnopolsky MA
FAU - Bar-Or, Oded
AU  - Bar-Or O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040604
PL  - United States
TA  - Pediatr Res
JT  - Pediatric research
JID - 0100714
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
CIN - Pediatr Res. 2004 Oct;56(4):664-5; author reply 665-6. PMID: 15319465
MH  - Adult
MH  - Blood Glucose/metabolism
MH  - Child
MH  - Dietary Carbohydrates/*metabolism
MH  - *Exercise
MH  - Humans
MH  - Immune System/*physiology
MH  - Interleukin-6/metabolism
MH  - Lymphocyte Subsets/immunology
MH  - Male
MH  - T-Lymphocytes/immunology
MH  - Tumor Necrosis Factor-alpha/metabolism
EDAT- 2004/06/08 05:00
MHDA- 2005/07/16 09:00
CRDT- 2004/06/08 05:00
PHST- 2004/06/08 05:00 [pubmed]
PHST- 2005/07/16 09:00 [medline]
PHST- 2004/06/08 05:00 [entrez]
AID - 01.PDR.0000132852.29770.C5 [pii]
AID - 10.1203/01.PDR.0000132852.29770.C5 [doi]
PST - ppublish
SO  - Pediatr Res. 2004 Aug;56(2):227-34. doi: 10.1203/01.PDR.0000132852.29770.C5. Epub 
      2004 Jun 4.