PMID- 1518156
OWN - NLM
STAT- MEDLINE
DCOM- 19921006
LR  - 20110727
IS  - 0047-1852 (Print)
IS  - 0047-1852 (Linking)
VI  - 50
IP  - 6
DP  - 1992 Jun
TI  - [Abnormalities of the retinoblastoma susceptibility gene (RB) in hematologic 
      malignancies].
PG  - 1347-52
AB  - The retinoblastoma susceptibility gene (RB) is expressed in all lineages of 
      normal hematopoietic cells and plays an important role in controlling cell cycle 
      progression at G1/S. Abnormalities of the RB gene may, therefore, predispose to 
      the development of hematologic malignancies. DNA rearrangement was reported to be 
      present in 1.5-12.1% of cases with primary leukemias and the absence of the RB 
      gene product was also observed in 6.3-23.2%. The abnormalities were frequently 
      observed in blastic crisis of CML, especially of the megakaryoblastic phenotype, 
      AML with monocytic differentiation and Ph1-positive leukemias. These results 
      indicate that abnormalities of RB are relatively common in hematologic 
      malignancies and loss of RB function may contribute to the altered growth of 
      these cells.
FAU - Furukawa, Y
AU  - Furukawa Y
AD  - Division of Hemopoiesis, Jichi Medical School.
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Rinsho
JT  - Nihon rinsho. Japanese journal of clinical medicine
JID - 0420546
SB  - IM
MH  - Blast Crisis
MH  - Cell Cycle
MH  - Gene Rearrangement
MH  - Genes, Retinoblastoma/*genetics
MH  - Genes, Tumor Suppressor/*physiology
MH  - Hematopoietic Stem Cells/cytology
MH  - Humans
MH  - Leukemia/etiology/*genetics/pathology
MH  - Phosphorylation
EDAT- 1992/06/01 00:00
MHDA- 1992/06/01 00:01
CRDT- 1992/06/01 00:00
PHST- 1992/06/01 00:00 [pubmed]
PHST- 1992/06/01 00:01 [medline]
PHST- 1992/06/01 00:00 [entrez]
PST - ppublish
SO  - Nihon Rinsho. 1992 Jun;50(6):1347-52.