PMID- 15184986
OWN - NLM
STAT- MEDLINE
DCOM- 20050217
LR  - 20181113
IS  - 0946-2716 (Print)
IS  - 0946-2716 (Linking)
VI  - 82
IP  - 9
DP  - 2004 Sep
TI  - Role of Id proteins in B lymphocyte activation: new insights from knockout mouse 
      studies.
PG  - 592-9
AB  - Id (inhibitor of differentiation) proteins play important roles in cell 
      differentiation, cell cycle control, and apoptosis. They act as negative 
      regulators of basic helix-loop-helix-type transcription factors, which positively 
      regulate differentiation of various cell types. Id proteins work to block B 
      lymphocyte (B cell) maturation at an early differentiation step, as demonstrated 
      by gain-of-function studies. In recent years a series of gene-targeted mice 
      lacking different Ids have been generated. Analyses of these gene-targeted mice 
      provide information useful for understanding the physiological roles of Ids in B 
      cell biology. Id3 is required for proper B cell functions and acts by controlling 
      the cell cycle. Upon B cell activation, Id2 acts as a negative regulator to 
      prevent potentially harmful effects brought about by excessive immunological 
      reactions; one of its special roles is to maintain low serum concentrations of 
      immunoglobulin E (IgE). The Id2 protein does this by antagonizing E2A and Pax5 
      activities, both of which are required for proper B cell activation. This review 
      presents several new insights into B cell differentiation and activation programs 
      and the physiological role of Id proteins in B cell activation.
FAU - Sugai, Manabu
AU  - Sugai M
AD  - Center for Molecular Biology and Genetics, Kyoto University, 53 
      Shogoin-Kawahara-cho, Sakyo-ku, 606-8507 Kyoto, Japan. msugai@virus.kyoto-u.ac.jp
FAU - Gonda, Hiroyuki
AU  - Gonda H
FAU - Nambu, Yukiko
AU  - Nambu Y
FAU - Yokota, Yoshifumi
AU  - Yokota Y
FAU - Shimizu, Akira
AU  - Shimizu A
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20040604
PL  - Germany
TA  - J Mol Med (Berl)
JT  - Journal of molecular medicine (Berlin, Germany)
JID - 9504370
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Idb2 protein, mouse)
RN  - 0 (Inhibitor of Differentiation Protein 2)
RN  - 0 (Inhibitor of Differentiation Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (PAX5 Transcription Factor)
RN  - 0 (Pax5 protein, mouse)
RN  - 0 (Repressor Proteins)
RN  - 0 (Tcf3 protein, mouse)
RN  - 0 (Transcription Factors)
RN  - 0 (Transforming Growth Factor beta)
RN  - 147785-34-0 (ID3 protein, human)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.5.4.- (AICDA (activation-induced cytidine deaminase))
RN  - EC 3.5.4.5 (Cytidine Deaminase)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/*immunology
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - Cell Cycle/physiology
MH  - Cytidine Deaminase/biosynthesis
MH  - DNA-Binding Proteins/antagonists & inhibitors/deficiency/genetics/*physiology
MH  - Immunoglobulin Class Switching
MH  - Immunoglobulin E/blood
MH  - Inhibitor of Differentiation Protein 2
MH  - Inhibitor of Differentiation Proteins
MH  - Lymphocyte Activation/*physiology
MH  - Mice
MH  - Mice, Knockout
MH  - Neoplasm Proteins/deficiency/genetics/*physiology
MH  - PAX5 Transcription Factor
MH  - Repressor Proteins/genetics/*physiology
MH  - Transcription Factors/antagonists & inhibitors/deficiency/genetics/*physiology
MH  - Transforming Growth Factor beta/physiology
RF  - 72
EDAT- 2004/06/09 05:00
MHDA- 2005/02/18 09:00
CRDT- 2004/06/09 05:00
PHST- 2004/03/02 00:00 [received]
PHST- 2004/05/12 00:00 [accepted]
PHST- 2004/06/09 05:00 [pubmed]
PHST- 2005/02/18 09:00 [medline]
PHST- 2004/06/09 05:00 [entrez]
AID - 10.1007/s00109-004-0562-z [doi]
PST - ppublish
SO  - J Mol Med (Berl). 2004 Sep;82(9):592-9. doi: 10.1007/s00109-004-0562-z. Epub 2004 
      Jun 4.