PMID- 15185972
OWN - NLM
STAT- MEDLINE
DCOM- 20041221
LR  - 20190727
IS  - 0040-8727 (Print)
IS  - 0040-8727 (Linking)
VI  - 203
IP  - 1
DP  - 2004 May
TI  - The role of beta2 microglobulin levels in monitoring chronic hepatitis B.
PG  - 53-7
AB  - Beta2 microglobulin is one of the domains of the histocompatibility class I human 
      leukocyte antigen (HLA) antigen. In hepatitis infection the presentation of the 
      viral antigen on the hepatocyte in the presence of class I HLA antigens plays a 
      significant role in the elimination of the virus. The aim of the study was to 
      estimate the serum beta2 microglobulin levels in cases of chronic hepatitis B 
      infection. Serum beta2 microglobulin levels were assessed in 65 cases with 
      chronic hepatitis B infection including 29 pediatric and 36 adult patients as the 
      study group and in 30 cases as seronegative control group. Beta2 microglobulin 
      level was found significantly higher in chronic active Hepatitis B virus (HBV) 
      patients compared to the asymptomatic HBV carriers and also in the chronic active 
      HBV patients compared to control group. We are of the opinion that beta2 
      microglobulin concentration is an indicator for monitoring chronic active HBV 
      infections at the asymptomatic hepatitis B virus carrier patients, thus would 
      lead to early initiation of Interferon (IFN) treatment and to monitor the 
      effectiveness of the therapy.
FAU - Yegane, Selma
AU  - Yegane S
AD  - Clinical Microbiology Laboratory, International Moris Sinasi Children's Hospital, 
      Manisa, Turkey.
FAU - Revanli, Melek
AU  - Revanli M
FAU - Taneli, Fatma
AU  - Taneli F
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Tohoku J Exp Med
JT  - The Tohoku journal of experimental medicine
JID - 0417355
RN  - 0 (beta 2-Microglobulin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Hepatitis B, Chronic/*blood/*diagnosis
MH  - Humans
MH  - beta 2-Microglobulin/*blood
EDAT- 2004/06/10 05:00
MHDA- 2004/12/22 09:00
CRDT- 2004/06/10 05:00
PHST- 2004/06/10 05:00 [pubmed]
PHST- 2004/12/22 09:00 [medline]
PHST- 2004/06/10 05:00 [entrez]
AID - 10.1620/tjem.203.53 [doi]
PST - ppublish
SO  - Tohoku J Exp Med. 2004 May;203(1):53-7. doi: 10.1620/tjem.203.53.