PMID- 1518658
OWN - NLM
STAT- MEDLINE
DCOM- 19921008
LR  - 20180216
IS  - 0301-1569 (Print)
IS  - 0301-1569 (Linking)
VI  - 54
IP  - 3
DP  - 1992
TI  - Histochemical localization of glycoconjugates in the developing endolymphatic sac 
      and vestibular end organs of the mouse.
PG  - 124-9
AB  - The distribution of glycoconjugates in the endolymphatic sac (ES) and vestibular 
      end organs from the 12th gestational day (GD) in the developing mouse to the 6th 
      day after birth was analyzed using six biotinylated lectins: wheat germ 
      agglutinin (WGA), Abrus precatorius agglutinin (APA), Ulex europaeus agglutinin I 
      (UEA-I), Ricinus communis agglutinin 120 (RCA120), Helix pomatia agglutinin 
      (HPA), concanavalin A (conA). In the 13th and 15th GD sections, the luminal 
      contents in the fetal ES were strongly labelled with lectins, while only a small 
      amount of substance in the ES was labelled with lectins after the 17th GD. In the 
      13th GD sections, before the cupula and otoconia were formed, the fetal ES 
      started to produce glycoconjugates labelled with WGA, APA, RCA120 and ConA. In 
      the 17th GD sections, the immature cupula and otoconia were strongly labelled 
      with WGA, APA and RCA120. Sugar residues stained by lectins detected in the 
      substance of the fetal ES were the same as those found in the immature cupula and 
      otoconia. HPA only stained the ES epithelium around the 13th and 15th GD. The 
      fetal ES may interact with the formation of the cupula and otoconia, especially 
      in the early stage during evolution and that HPA-reactive glycoconjugates may be 
      related to the intracellular elements of the ES epithelium only during a 
      well-defined phase of development.
FAU - Yamashita, H
AU  - Yamashita H
AD  - Department of Otolaryngology, Karolinska Hospital, Stockholm, Sweden.
FAU - Bagger-Sjoback, D
AU  - Bagger-Sjoback D
FAU - Sekitani, T
AU  - Sekitani T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - ORL J Otorhinolaryngol Relat Spec
JT  - ORL; journal for oto-rhino-laryngology and its related specialties
JID - 0334721
RN  - 0 (Glycoconjugates)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Endolymphatic Sac/*chemistry/embryology
MH  - Glycoconjugates/*analysis
MH  - Histocytochemistry
MH  - Mice
MH  - Vestibule, Labyrinth/*chemistry/embryology
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
AID - 10.1159/000276280 [doi]
PST - ppublish
SO  - ORL J Otorhinolaryngol Relat Spec. 1992;54(3):124-9. doi: 10.1159/000276280.