PMID- 15188370
OWN - NLM
STAT- MEDLINE
DCOM- 20040708
LR  - 20131121
IS  - 0004-3591 (Print)
IS  - 0004-3591 (Linking)
VI  - 50
IP  - 6
DP  - 2004 Jun
TI  - Increased interleukin-18 expression in bone marrow of a patient with systemic 
      juvenile idiopathic arthritis and unrecognized macrophage-activation syndrome.
PG  - 1935-8
AB  - The aberrant induction of proinflammatory cytokines is considered to be crucial 
      in the pathogenesis of systemic juvenile idiopathic arthritis and adult-onset 
      Still's disease. Interleukin-18 (IL-18) in particular has been reported to be a 
      candidate for the key cytokine in both diseases; however, the origin of IL-18 is 
      unclear. To clarify the origin, we investigated specimens from various organs 
      obtained during autopsy of a child with systemic JIA and macrophage activation 
      syndrome, using immunohistochemical staining. Our results showed a high number of 
      cells expressing IL-18 in the bone marrow but not in the other organs. This 
      finding suggests that bone marrow is the origin of increased serum IL-18 and 
      raises the possibility that other proinflammatory cytokines are also induced by 
      IL-18 in bone marrow in this disease. Bone marrow may be an essential organ in 
      the pathogenesis of systemic JIA.
FAU - Maeno, Nobuaki
AU  - Maeno N
AD  - Department of Infection and Immunity, Kagoshima University Graduate School of 
      Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan. 
      maeno@m3.kufm.kagoshima-u.ac.jp
FAU - Takei, Syuji
AU  - Takei S
FAU - Imanaka, Hiroyuki
AU  - Imanaka H
FAU - Yamamoto, Kimie
AU  - Yamamoto K
FAU - Kuriwaki, Kazumi
AU  - Kuriwaki K
FAU - Kawano, Yoshifumi
AU  - Kawano Y
FAU - Oda, Hiroshi
AU  - Oda H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arthritis Rheum
JT  - Arthritis and rheumatism
JID - 0370605
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Arthritis, Juvenile/*immunology/metabolism/*pathology
MH  - Bone Marrow/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Infant
MH  - Interleukin-18/*metabolism
MH  - Macrophages/immunology/*pathology
EDAT- 2004/06/10 05:00
MHDA- 2004/07/09 05:00
CRDT- 2004/06/10 05:00
PHST- 2004/06/10 05:00 [pubmed]
PHST- 2004/07/09 05:00 [medline]
PHST- 2004/06/10 05:00 [entrez]
AID - 10.1002/art.20268 [doi]
PST - ppublish
SO  - Arthritis Rheum. 2004 Jun;50(6):1935-8. doi: 10.1002/art.20268.