PMID- 15189504
OWN - NLM
STAT- MEDLINE
DCOM- 20041223
LR  - 20171116
IS  - 1320-5463 (Print)
IS  - 1320-5463 (Linking)
VI  - 54
IP  - 7
DP  - 2004 Jul
TI  - Frequent expression of CD30 antigen in the primary gastric non-B, non-Hodgkin 
      lymphomas.
PG  - 503-9
AB  - Most primary gastric lymphomas are of B-cell origin. Fourteen cases of primary 
      gastric non-B, non-Hodgkin lymphomas were studied to evaluate their 
      clinicopathological and immunophenotypic findings. The cases were comprised of 11 
      men and three women, with a median age of 56.5 years. Most patients underwent 
      surgery either with or without chemotherapy, exhibiting a 5 year survival rate of 
      57.5%. Morphologically, the neoplastic cells showed various histological 
      features, such as anaplastic large cell lymphoma (ALCL) (n = 3), peripheral 
      T-cell lymphoma, unspecified, large (n = 4), medium-sized (n = 2) and mixed cell 
      (n = 5). Two cases displayed a non-B, non-T cell phenotype, whereas the remaining 
      cases displayed a T-cell phenotype. Six cases were CD4+, while two were CD8+. The 
      neoplastic cells were CD30+ in 10 cases. TIA-1 was positive in six cases. In one 
      case, anaplastic large cell lymphoma kinase (ALK) was identified with 
      immunostaining and chromosomal rearrangement of ALK was detected by fluorescence 
      in situ hybridization (FISH). In conclusion, although the mechanism of CD30 
      expression is unknown, primary gastric non-B, non-Hodgkin lymphomas tend to 
      express CD30. We consider that some of the cases in the present study may be 
      derived from cytotoxic T cells, similar to systemic and cutaneous ALCL, the 
      majority of which exhibit TIA-1.
FAU - Iwamizu-Watanabe, Sachiko
AU  - Iwamizu-Watanabe S
AD  - Department of Pathology of Molecular Diagnosis and Biological Response, Nagoya 
      University Graduate School of Medicine, Nagoya, Japan.
FAU - Yamashita, Yoriko
AU  - Yamashita Y
FAU - Yatabe, Yasushi
AU  - Yatabe Y
FAU - Nakamura, Shigeo
AU  - Nakamura S
FAU - Mori, Naoyoshi
AU  - Mori N
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (Ki-1 Antigen)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Ki-1 Antigen/*metabolism
MH  - Lymphoma, Large-Cell, Anaplastic/*metabolism/pathology
MH  - Lymphoma, Non-Hodgkin/*metabolism/mortality/pathology
MH  - Lymphoma, T-Cell, Peripheral/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Stomach Neoplasms/*metabolism/mortality/pathology
MH  - Survival Rate
EDAT- 2004/06/11 05:00
MHDA- 2004/12/24 09:00
CRDT- 2004/06/11 05:00
PHST- 2004/06/11 05:00 [pubmed]
PHST- 2004/12/24 09:00 [medline]
PHST- 2004/06/11 05:00 [entrez]
AID - PIN1657 [pii]
AID - 10.1111/j.1440-1827.2004.01657.x [doi]
PST - ppublish
SO  - Pathol Int. 2004 Jul;54(7):503-9. doi: 10.1111/j.1440-1827.2004.01657.x.