PMID- 15190420
OWN - NLM
STAT- MEDLINE
DCOM- 20040721
LR  - 20061115
IS  - 0028-2685 (Print)
IS  - 0028-2685 (Linking)
VI  - 51
IP  - 2
DP  - 2004
TI  - Allogeneic peripheral blood stem cell transplantations in children--a single 
      center experience.
PG  - 110-6
AB  - We analyzed 30 peripheral blood stem cell transplantations (PBSCT) from 25 human 
      leukocyte antigen (HLA) matched sibling donors (MSD) and 4 HLA-matched unrelated 
      donors (MUD) in 29 patients, done between November 1996 and March 2003. Patients 
      aged 3 to 17 years underwent allogeneic PBSCT for malignant (16 patients) and 
      non-malignant (13 patients) diseases. Sibling donors aged 3 to 23 years were 
      given granulocyte colony-stimulating factor (G-CSF) 5-10 microg/kg/day for 4 to 5 
      days. All but one of the 29 donors underwent one single leukapheresis for stem 
      cell collection. The patients received a median of 4.2 x 10(6) CD34+ cells/kg of 
      body weight, they all engrafted after a median of 13.5 days (range 10-25 days). 
      Acute graft-versus-host disease (GVHD) grade II to IV developed in 11 of 26 MSD 
      transplants and in all 4 patients after MUD PBSCT. Eleven of 27 evaluable 
      patients experienced chronic GVHD. After a median follow-up of 662 days, 20 out 
      of 29 patients (69%) are alive, three of them need systemic immunosuppression for 
      chronic GVHD. Six patients experienced relapse of their underlying malignant 
      disease, one of them still alive in complete remission. Two patients died of 
      grade IV acute GVHD and two others due to an opportunistic infection. Based upon 
      our experience, PBSCT is a feasible and safe method for both pediatric donors and 
      patients. It is associated with rapid engraftment, no greater incidence of acute 
      but a higher incidence of chronic GVHD as compared to bone marrow transplantation 
      (BMT) and therefore suitable mainly for children suffering from malignant 
      diseases.
FAU - Sufliarska, S
AU  - Sufliarska S
AD  - Bone Marrow Transplantation Unit, Department of Pediatrics, Comenius University 
      Medical School, Bratislava, Slovak Republic.
FAU - Horakova, J
AU  - Horakova J
FAU - Bodova, I
AU  - Bodova I
FAU - Martinka, J
AU  - Martinka J
FAU - Hrubisko, M
AU  - Hrubisko M
FAU - Kovacs, L
AU  - Kovacs L
FAU - Jancovicova, K
AU  - Jancovicova K
FAU - Lukac, J
AU  - Lukac J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Slovakia
TA  - Neoplasma
JT  - Neoplasma
JID - 0377266
RN  - 143011-72-7 (Granulocyte Colony-Stimulating Factor)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Female
MH  - Graft vs Host Disease
MH  - Granulocyte Colony-Stimulating Factor/pharmacology
MH  - Hematologic Diseases/therapy
MH  - Hematologic Neoplasms/*therapy
MH  - Histocompatibility Testing
MH  - Humans
MH  - Leukapheresis
MH  - Male
MH  - Peripheral Blood Stem Cell Transplantation/*methods
MH  - Recurrence
MH  - Siblings
MH  - Time Factors
MH  - Transplantation, Homologous/*methods
MH  - Treatment Outcome
EDAT- 2004/06/11 05:00
MHDA- 2004/07/22 05:00
CRDT- 2004/06/11 05:00
PHST- 2004/06/11 05:00 [pubmed]
PHST- 2004/07/22 05:00 [medline]
PHST- 2004/06/11 05:00 [entrez]
PST - ppublish
SO  - Neoplasma. 2004;51(2):110-6.