PMID- 15191524
OWN - NLM
STAT- MEDLINE
DCOM- 20041229
LR  - 20111117
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 64
IP  - 1
DP  - 2004 Jul
TI  - Association between human leukocyte antigen-G genotype and success of in vitro 
      fertilization and pregnancy outcome.
PG  - 66-9
AB  - To determine if a 14-bp deletion/insertion polymorphism in the 3'-untranslated 
      region of exon 8 of the gene encoding human leukocyte antigen (HLA)-G in a 
      homozygous form is associated with repeated, unsuccessful in vitro fertilization 
      (IVF) treatments, and with increased risk of recurrent spontaneous abortions 
      (RSA), 29 white women undergoing IVF treatments, 61 RSA women and 93 fertile 
      controls were HLA-G genotype. The HLA-G genotype, homozygous for the presence of 
      the 14 bp sequence in exon 8, was significantly associated with reduced fertility 
      with respect to unsuccessful IVF treatments and increased risk of recurrent 
      miscarriage (combined P < 0.01). The 14-bp insertion/deletion polymorphism is 
      associated with differences in HLA-G mRNA alternative splicing and levels of 
      HLA-G. This might affect a possible immunomodulatory role of HLA-G expression in 
      both the mother and foetus during implantation and pregnancy.
FAU - Hviid, T V F
AU  - Hviid TV
AD  - Department of Clinical Biochemistry, Copenhagen University Hospital, 
      Rigshospitalet, Copenhagen O, Denmark. hviid@dadlnet.dk
FAU - Hylenius, S
AU  - Hylenius S
FAU - Lindhard, A
AU  - Lindhard A
FAU - Christiansen, O B
AU  - Christiansen OB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Abortion, Habitual/genetics/immunology
MH  - Adult
MH  - Alleles
MH  - Case-Control Studies
MH  - Exons
MH  - Female
MH  - Fertilization in Vitro
MH  - Genotype
MH  - HLA Antigens/*genetics
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Homozygote
MH  - Humans
MH  - Infant, Newborn
MH  - Polymorphism, Genetic
MH  - Pregnancy
MH  - Pregnancy Outcome
EDAT- 2004/06/12 05:00
MHDA- 2004/12/30 09:00
CRDT- 2004/06/12 05:00
PHST- 2004/06/12 05:00 [pubmed]
PHST- 2004/12/30 09:00 [medline]
PHST- 2004/06/12 05:00 [entrez]
AID - TAN239 [pii]
AID - 10.1111/j.1399-0039.2004.00239.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2004 Jul;64(1):66-9. doi: 10.1111/j.1399-0039.2004.00239.x.