PMID- 15193446
OWN - NLM
STAT- MEDLINE
DCOM- 20040727
LR  - 20211203
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 152
IP  - 1
DP  - 2004 Jul 1
TI  - Cryptic deletion involving the ATM locus at 11q22.3 approximately q23.1 in B-cell 
      chronic lymphocytic leukemia and related disorders.
PG  - 72-6
AB  - B-cell chronic lymphocytic leukemia (B-CLL) follows a heterogeneous clinical 
      course, and several biological parameters have been investigated to try to 
      predict its clinical outcome. New staging systems including cytogenetics and CD38 
      expression as predictive values have been developed. Deletions of 11q22.3 
      approximately q23.1 detected at diagnosis in cases of CLL patients have been 
      associated with a relatively aggressive disease. This region, which contains the 
      ataxia telangiectasia mutated (ATM) locus, may be implicated in the pathogenesis 
      of lymphoid malignancies. We developed a set of dual-color specific probes to 
      evaluate the ATM deletion by means of fluorescence in situ hybridization (FISH). 
      We also used flow cytometry to investigate CD38 expression. Forty-one patients 
      with CLL or low-grade B-cell lymphomas were studied at diagnosis or before 
      treatment. FISH showed that only three CLL patients had deletions in the 11q23 
      locus; all three had progressive disease and were resistant to treatment. These 
      data show that our FISH set of probes efficiently detects ATM deletions in CLL. 
      No correlation was found between ATM deletions and CD38 expression level. These 
      results confirm the prognostic significance of ATM deletions in CLL.
FAU - Eclache, Virginie
AU  - Eclache V
AD  - Laboratoire d'Hematologie, Unite Fonctionelle d'Hematologie, Hopital Jean 
      Verdier, Avenue du 14 Juillet, 93145 Bondy Cedex, France. 
      virginie.eclache@jvr.ap-hop-paris.fr
FAU - Caulet-Maugendre, Sylvie
AU  - Caulet-Maugendre S
FAU - Poirel, Helene A
AU  - Poirel HA
FAU - Djemai, Mohand
AU  - Djemai M
FAU - Robert, Jacqueline
AU  - Robert J
FAU - Lejeune, Francoise
AU  - Lejeune F
FAU - Raphael, Martine
AU  - Raphael M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Antigens, CD)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Tumor Suppressor Proteins)
RN  - EC 2.7.11.1 (ATM protein, human)
RN  - EC 2.7.11.1 (Ataxia Telangiectasia Mutated Proteins)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 3.2.2.5 (ADP-ribosyl Cyclase)
RN  - EC 3.2.2.5 (CD38 protein, human)
RN  - EC 3.2.2.6 (ADP-ribosyl Cyclase 1)
SB  - IM
MH  - ADP-ribosyl Cyclase/metabolism
MH  - ADP-ribosyl Cyclase 1
MH  - Adult
MH  - Aged
MH  - Antigens, CD/metabolism
MH  - Ataxia Telangiectasia/genetics
MH  - Ataxia Telangiectasia Mutated Proteins
MH  - Cell Cycle Proteins
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - DNA-Binding Proteins
MH  - Disease Progression
MH  - Female
MH  - Flow Cytometry
MH  - Follow-Up Studies
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Interphase
MH  - Karyotyping
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis/*genetics/therapy
MH  - Leukemia, Prolymphocytic/diagnosis/*genetics/therapy
MH  - Lymphoma/diagnosis/*genetics/therapy
MH  - Male
MH  - Membrane Glycoproteins
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Protein Serine-Threonine Kinases/*genetics
MH  - Tumor Suppressor Proteins
EDAT- 2004/06/15 05:00
MHDA- 2004/07/28 05:00
CRDT- 2004/06/15 05:00
PHST- 2003/08/29 00:00 [received]
PHST- 2003/09/29 00:00 [revised]
PHST- 2003/10/13 00:00 [accepted]
PHST- 2004/06/15 05:00 [pubmed]
PHST- 2004/07/28 05:00 [medline]
PHST- 2004/06/15 05:00 [entrez]
AID - S0165460803004631 [pii]
AID - 10.1016/j.cancergencyto.2003.10.010 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2004 Jul 1;152(1):72-6. doi: 
      10.1016/j.cancergencyto.2003.10.010.