PMID- 15193448
OWN - NLM
STAT- MEDLINE
DCOM- 20040727
LR  - 20091119
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 152
IP  - 1
DP  - 2004 Jul 1
TI  - A t(1;9)(q23.3 approximately q25;q34) affecting the ABL1 gene in a biphenotypic 
      leukemia.
PG  - 81-3
AB  - Recurring chromosome translocations, which are found in leukemia, can result in 
      the inappropriate expression of oncogenes or in the formation of chimeric genes 
      that code for structurally and functionally abnormal proteins. The chromosomal 
      t(1;9)(q23.3 approximately q25;q34) was found in a patient with biphenotypic 
      leukemia. Fluorescence in situ hybridization (FISH) analysis revealed that the 
      break on chromosome 9 occurred in the ABL1 gene. The breakpoint on chromosome 1 
      occurred distal to the PBX1 gene at 1q23.3, as shown by FISH using BAC 
      RP11-503N16 and RP11-403P14, which flank the PBX1 locus; hence, the ABL1 gene can 
      be fused with another gene distal to PBX1 gene.
FAU - Gonzalez Garcia, Juan Ramon
AU  - Gonzalez Garcia JR
AD  - Laboratorio de Citogenetica, Centro de Investigacion Biomedica de Occidente, 
      Centro Medico Nacional de Occidente, Instituto Mexicano del Seguro Social 
      (CIBO-IMSS), Colonia Independencia, Guadalajara, Jalisco, Mexico. 
      jrgg_gene@hotmail.com
FAU - Bohlander, Stefan K
AU  - Bohlander SK
FAU - Gutierrez Angulo, Melva
AU  - Gutierrez Angulo M
FAU - Esparza Flores, Maria Amparo
AU  - Esparza Flores MA
FAU - Picos Cardenas, Veronica Judith
AU  - Picos Cardenas VJ
FAU - Meza Espinoza, Juan Pablo
AU  - Meza Espinoza JP
FAU - Ayala Madrigal, Maria de la Luz
AU  - Ayala Madrigal Mde L
FAU - Rivera, Horacio
AU  - Rivera H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - EC 2.7.10.2 (Proto-Oncogene Proteins c-abl)
SB  - IM
MH  - Adolescent
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Chromosome Breakage
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Chromosomes, Human, Pair 9/*genetics
MH  - Gene Rearrangement
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia/drug therapy/*genetics/pathology
MH  - Male
MH  - Phenotype
MH  - Proto-Oncogene Proteins c-abl/*genetics
MH  - Sensitivity and Specificity
MH  - *Translocation, Genetic
EDAT- 2004/06/15 05:00
MHDA- 2004/07/28 05:00
CRDT- 2004/06/15 05:00
PHST- 2003/07/31 00:00 [received]
PHST- 2003/10/17 00:00 [revised]
PHST- 2003/10/20 00:00 [accepted]
PHST- 2004/06/15 05:00 [pubmed]
PHST- 2004/07/28 05:00 [medline]
PHST- 2004/06/15 05:00 [entrez]
AID - S0165460803004679 [pii]
AID - 10.1016/j.cancergencyto.2003.10.014 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2004 Jul 1;152(1):81-3. doi: 
      10.1016/j.cancergencyto.2003.10.014.