PMID- 15193537
OWN - NLM
STAT- MEDLINE
DCOM- 20040825
LR  - 20121115
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1013
IP  - 2
DP  - 2004 Jul 9
TI  - WAY100635 and female rat lordosis behavior.
PG  - 260-3
AB  - Sexually receptive proestrous rats with bilateral cannulae in the ventromedial 
      nucleus of the hypothalamus (VMN) were infused with 200 ng of 
      (+/-)-8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) or with 8-OH-DPAT plus 
      varying concentrations (200 to 2000 ng) of the 5-HT1A receptor antagonist, 
      N-[2[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]N-(2-pyridinyl)cyclohexanecarboxamide 
      trihydrochloride (WAY100635). 8-OH-DPAT inhibited lordosis behavior within 15 min 
      of the infusion and every dose of WAY100635 prevented the inhibition. When 
      non-sexually receptive, ovariectomized rats, hormonally primed with 0.5 microg 
      estradiol benzoate and 500 microg progesterone, were infused with WAY100635 (400 
      to 2000 ng), the 5-HT1A receptor antagonist did not facilitate lordosis 
      responding. These findings support earlier findings that activation of 5-HT1A 
      receptors in the mediobasal hypothalamus inhibits lordosis behavior. However, 
      they further demonstrate that tonic activation of 5-HT1A receptors is not 
      responsible for the absence of sexual receptivity in suboptimally hormonally 
      primed ovariectomized rats.
FAU - Uphouse, Lynda
AU  - Uphouse L
AD  - Department of Biology, Texas Woman's University, Denton, TX 76204, USA. 
      LUphouse@twu.edu
FAU - Wolf, Amy
AU  - Wolf A
LA  - eng
GR  - GM55380/GM/NIGMS NIH HHS/United States
GR  - HD 28419/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Piperazines)
RN  - 0 (Pyridines)
RN  - 0 (Serotonin Antagonists)
RN  - 0 (Serotonin Receptor Agonists)
RN  - 71IH826FEG 
      (N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide)
RN  - 78950-78-4 (8-Hydroxy-2-(di-n-propylamino)tetralin)
SB  - IM
MH  - 8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology
MH  - Animals
MH  - Female
MH  - Ovariectomy
MH  - Piperazines/*pharmacology
MH  - *Posture
MH  - Proestrus/physiology
MH  - Pyridines/*pharmacology
MH  - Rats
MH  - Rats, Inbred F344
MH  - Serotonin Antagonists/*pharmacology
MH  - Serotonin Receptor Agonists/pharmacology
MH  - Sexual Behavior, Animal/*drug effects
MH  - Ventromedial Hypothalamic Nucleus/*drug effects/physiology
EDAT- 2004/06/15 05:00
MHDA- 2004/08/26 05:00
CRDT- 2004/06/15 05:00
PHST- 2004/04/03 00:00 [accepted]
PHST- 2004/06/15 05:00 [pubmed]
PHST- 2004/08/26 05:00 [medline]
PHST- 2004/06/15 05:00 [entrez]
AID - S0006899304005773 [pii]
AID - 10.1016/j.brainres.2004.04.013 [doi]
PST - ppublish
SO  - Brain Res. 2004 Jul 9;1013(2):260-3. doi: 10.1016/j.brainres.2004.04.013.