PMID- 15194206
OWN - NLM
STAT- MEDLINE
DCOM- 20041007
LR  - 20161028
IS  - 0376-8716 (Print)
IS  - 0376-8716 (Linking)
VI  - 74
IP  - 3
DP  - 2004 Jun 11
TI  - Comparison of the discriminative stimulus effects of 
      3,4-methylenedioxymethamphetamine (MDMA) and cocaine: asymmetric generalization.
PG  - 281-7
AB  - Evidence suggests that +/- 3,4-methylenedioxymethamphetamine (MDMA) and 
      psychostimulants produce similar but non-identical stimulus effects in animals. 
      To examine this hypothesis, groups of rats were trained to discriminate either 
      MDMA (1.5 mg/kg) or cocaine (8 mg/kg) from saline vehicle using a two-lever 
      operant procedure under a variable interval (VI) 15 s schedule of reinforcement. 
      Once the animals were trained, tests of stimulus generalization were conducted 
      with +/- MDMA, cocaine, S+ MDMA, and R- MDMA. As previously demonstrated, both S+ 
      MDMA and R- MDMA (ED50 = 0.8 and 1.2 mg/kg, respectively) substituted for +/- 
      MDMA. Stimulus generalization also occurred upon administration of cocaine (ED50 
      = 4.6 mg/kg) to the +/- MDMA-trained animals. In the cocaine-trained animals, 
      however, stimulus generalization did not occur to +/- MDMA, S+ MDMA nor R- MDMA. 
      Receptor binding profiles for MDMA and cocaine were compared in an effort to 
      identify any novel and common receptor-based mechanism(s) to explain stimulus 
      generalization of MDMA-trained animals to the effects of cocaine, but only their 
      actions on neurotransmitter transporters seem applicable. Taken together, the 
      results indicate that stimulus substitution between MDMA and cocaine is 
      asymmetric and suggest that although similarities exist between the stimulus 
      actions of MDMA and cocaine, differences might be explained by their differential 
      effects on increasing synaptic concentrations of serotonin (5-HT), dopamine (DA), 
      and/or norepinephrine (NE).
FAU - Khorana, Nantaka
AU  - Khorana N
AD  - Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth 
      University, Richmond, VA 23298-0540, USA.
FAU - Pullagurla, Manik R
AU  - Pullagurla MR
FAU - Young, Richard
AU  - Young R
FAU - Glennon, Richard A
AU  - Glennon RA
LA  - eng
GR  - R01 DA001642/DA/NIDA NIH HHS/United States
GR  - DA-01642/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - I5Y540LHVR (Cocaine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Cocaine/metabolism/*pharmacology
MH  - Discrimination Learning/*drug effects/physiology
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/metabolism/*pharmacology
MH  - Protein Binding/drug effects/physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reaction Time/*drug effects/physiology
EDAT- 2004/06/15 05:00
MHDA- 2004/10/08 09:00
CRDT- 2004/06/15 05:00
PHST- 2003/08/19 00:00 [received]
PHST- 2003/12/09 00:00 [revised]
PHST- 2004/01/13 00:00 [accepted]
PHST- 2004/06/15 05:00 [pubmed]
PHST- 2004/10/08 09:00 [medline]
PHST- 2004/06/15 05:00 [entrez]
AID - S0376871604000092 [pii]
AID - 10.1016/j.drugalcdep.2004.01.005 [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 2004 Jun 11;74(3):281-7. doi: 
      10.1016/j.drugalcdep.2004.01.005.