PMID- 15195055
OWN - NLM
STAT- MEDLINE
DCOM- 20040629
LR  - 20091119
IS  - 0194-5998 (Print)
IS  - 0194-5998 (Linking)
VI  - 130
IP  - 6
DP  - 2004 Jun
TI  - c-met overexpression in supraglottic laryngeal squamous cell carcinoma and its 
      relation to lymph node metastases.
PG  - 698-703
AB  - BACKGROUND: The c-met oncogene encodes the receptor for the hepatocyte growth 
      factor/scatter factor (HGF/SF), which is known to have the effects of stimulation 
      of cell motility, dissociation of epithelial sheets, invasion of cellular matrix, 
      and induction of angiogenesis. Many studies in solid tumors have indicated a role 
      for c-met and HGF/SF in the progression of the disease. METHODS: The expression 
      of c-met in tissue specimens was studied by immunohistochemical examination in 60 
      patients with supraglottic laryngeal squamous cell carcinoma. Patients were 
      chosen such that there were 30 with lymph node metastases in the neck and 30 
      without metastases. TNM staging, differentiation, lymphovascular and perineural 
      invasion, and growth pattern for tumors were also recorded, and their relation to 
      lymph node metastases was analyzed. RESULTS: Overexpression of c-met was observed 
      in 90% of the cases at the primary site and in 83% of the cases with lymph node 
      metastases in the neck. Lymphovascular invasion (P = 0.005) and the N stage (P = 
      0.001) were found to be related to lymph node metastases, but other 
      variables-c-met overexpression, the T stage, perineural invasion, and growth 
      pattern-were found to have no relation to lymph node metastases in multivariate 
      analysis of the data with linear regression. CONCLUSIONS: c-met overexpression is 
      observed in both the primary site and the neck in supraglottic laryngeal squamous 
      cell carcinoma. We believe that it may have a role in the progression of 
      malignancy, but we were unable to find a definite relation between c-met 
      expression and lymph node metastases.
FAU - Yucel, O Taskin
AU  - Yucel OT
AD  - ENT Department, Hacettepe University Medical Faculty. tyucel@tr.net
FAU - Sungur, Arzu
AU  - Sungur A
FAU - Kaya, Sefa
AU  - Kaya S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Carcinoma, Squamous Cell/*genetics/metabolism/pathology
MH  - Glottis
MH  - Humans
MH  - Hypopharyngeal Neoplasms/*genetics/metabolism/pathology
MH  - Immunohistochemistry
MH  - Lymphatic Metastasis
MH  - Neck
MH  - Neoplasm Invasiveness
MH  - Neoplasm Staging
MH  - Perineum
MH  - Proto-Oncogene Proteins c-met/*genetics/metabolism
MH  - Vascular Neoplasms/metabolism/secondary
EDAT- 2004/06/15 05:00
MHDA- 2004/06/30 05:00
CRDT- 2004/06/15 05:00
PHST- 2004/06/15 05:00 [pubmed]
PHST- 2004/06/30 05:00 [medline]
PHST- 2004/06/15 05:00 [entrez]
AID - S0194599803021806 [pii]
AID - 10.1016/j.otohns.2003.09.031 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2004 Jun;130(6):698-703. doi: 
      10.1016/j.otohns.2003.09.031.