PMID- 15195087
OWN - NLM
STAT- MEDLINE
DCOM- 20040819
LR  - 20220408
IS  - 1078-8956 (Print)
IS  - 1078-8956 (Linking)
VI  - 10
IP  - 7
DP  - 2004 Jul
TI  - Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic 
      AMP-activated protein kinase.
PG  - 727-33
AB  - AMP-activated protein kinase (AMPK) functions as a fuel sensor in the cell and is 
      activated when cellular energy is depleted. Here we report that alpha-lipoic acid 
      (alpha-LA), a cofactor of mitochondrial enzymes, decreases hypothalamic AMPK 
      activity and causes profound weight loss in rodents by reducing food intake and 
      enhancing energy expenditure. Activation of hypothalamic AMPK reverses the 
      effects of alpha-LA on food intake and energy expenditure. 
      Intracerebroventricular (i.c.v.) administration of glucose decreases hypothalamic 
      AMPK activity, whereas inhibition of intracellular glucose utilization through 
      the administration of 2-deoxyglucose increases hypothalamic AMPK activity and 
      food intake. The 2-deoxyglucose-induced hyperphagia is reversed by inhibiting 
      hypothalamic AMPK. Our findings indicate that hypothalamic AMPK is important in 
      the central regulation of food intake and energy expenditure and that alpha-LA 
      exerts anti-obesity effects by suppressing hypothalamic AMPK activity.
FAU - Kim, Min-Seon
AU  - Kim MS
AD  - Department of Internal Medicine, University of Ulsan College of Medicine, 138-736 
      Poongnap-dong, Songpa-ku, Seoul 138-736, Korea.
FAU - Park, Joong-Yeol
AU  - Park JY
FAU - Namkoong, Cherl
AU  - Namkoong C
FAU - Jang, Pil-Geum
AU  - Jang PG
FAU - Ryu, Je-Won
AU  - Ryu JW
FAU - Song, Hai-Sun
AU  - Song HS
FAU - Yun, Ji-Young
AU  - Yun JY
FAU - Namgoong, Il-Seong
AU  - Namgoong IS
FAU - Ha, Joohun
AU  - Ha J
FAU - Park, In-Sun
AU  - Park IS
FAU - Lee, In-Kyu
AU  - Lee IK
FAU - Viollet, Benoit
AU  - Viollet B
FAU - Youn, Jang Hyun
AU  - Youn JH
FAU - Lee, Hong-Kyu
AU  - Lee HK
FAU - Lee, Ki-Up
AU  - Lee KU
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20040613
PL  - United States
TA  - Nat Med
JT  - Nature medicine
JID - 9502015
RN  - 0 (Anti-Obesity Agents)
RN  - 0 (Leptin)
RN  - 73Y7P0K73Y (Thioctic Acid)
RN  - EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases)
SB  - IM
CIN - Nat Med. 2004 Jul;10(7):681-2. PMID: 15229514
MH  - Animals
MH  - Anti-Obesity Agents/*pharmacology
MH  - Body Weight/drug effects
MH  - Cyclic AMP-Dependent Protein Kinases/*antagonists & inhibitors/physiology
MH  - Eating/drug effects
MH  - Energy Metabolism/drug effects
MH  - Enzyme Activation/drug effects
MH  - Hypothalamus/*drug effects/enzymology/physiology
MH  - Leptin/physiology
MH  - Mice
MH  - Muscle, Skeletal/drug effects/metabolism
MH  - Rats
MH  - Thioctic Acid/*pharmacology
EDAT- 2004/06/15 05:00
MHDA- 2004/08/20 05:00
CRDT- 2004/06/15 05:00
PHST- 2004/03/23 00:00 [received]
PHST- 2004/05/20 00:00 [accepted]
PHST- 2004/06/15 05:00 [pubmed]
PHST- 2004/08/20 05:00 [medline]
PHST- 2004/06/15 05:00 [entrez]
AID - nm1061 [pii]
AID - 10.1038/nm1061 [doi]
PST - ppublish
SO  - Nat Med. 2004 Jul;10(7):727-33. doi: 10.1038/nm1061. Epub 2004 Jun 13.