PMID- 15196084
OWN - NLM
STAT- MEDLINE
DCOM- 20050113
LR  - 20230124
IS  - 1600-6135 (Print)
IS  - 1600-6135 (Linking)
VI  - 4
IP  - 7
DP  - 2004 Jul
TI  - Acute polymyositis following renal transplantation.
PG  - 1204-7
AB  - Myositis is a rare complication following renal transplantation and is most 
      commonly the result of drug-mediated myotoxicity. Other causative disorders 
      include viral infection, electrolyte imbalance and myositis of autoimmune origin. 
      We describe a 60-year-old patient who developed acute polymyositis 4 weeks after 
      a 000 human leukocyte antigen (HLA) mismatch cadaveric renal transplant. 
      Following an uncomplicated transplant course with maintenance triple 
      immunosuppression (prednisolone, mycophenolate mofetil and cyclosporine), the 
      patient presented with severe symmetrical proximal muscle weakness associated 
      with a rise in serum creatine kinase to 46800 U/L. Electromyography confirmed 
      myopathic changes and muscle biopsy demonstrated extensive muscle-fiber necrosis 
      with an inflammatory infiltrate. There were no obviously culpable drugs and viral 
      studies were negative. Prompt initiation of high-dose steroid therapy led to 
      clinical and biochemical recovery. Acute polymyositis may occur following renal 
      transplantation. Potential mechanisms include viral antigen transmission or a 
      localized form of graft vs. host disease.
FAU - Courtney, Aisling E
AU  - Courtney AE
AD  - Regional Nephrology Unit, Belfast City Hospital, Belfast, UK. 
      aecourtney@doctors.org.uk
FAU - C Doherty, Ciaran
AU  - C Doherty C
FAU - Herron, Brian
AU  - Herron B
FAU - McCarron, Mark O
AU  - McCarron MO
FAU - Connolly, John K
AU  - Connolly JK
FAU - Jefferson, J Ashley
AU  - Jefferson JA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antigens)
RN  - 0 (Electrolytes)
RN  - 0 (HLA Antigens)
RN  - 0 (Immunosuppressive Agents)
RN  - 83HN0GTJ6D (Cyclosporine)
RN  - 9PHQ9Y1OLM (Prednisolone)
RN  - EC 2.7.3.2 (Creatine Kinase)
RN  - HU9DX48N0T (Mycophenolic Acid)
SB  - IM
MH  - Acute Disease
MH  - Anti-Inflammatory Agents/pharmacology
MH  - Antigens/chemistry
MH  - Creatine Kinase/blood
MH  - Cyclosporine/pharmacology
MH  - Electrolytes/metabolism
MH  - Electromyography
MH  - HLA Antigens/chemistry
MH  - Humans
MH  - Immunosuppression Therapy
MH  - Immunosuppressive Agents/pharmacology
MH  - Inflammation
MH  - Kidney Transplantation/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Muscles/pathology
MH  - Mycophenolic Acid/*analogs & derivatives/pharmacology
MH  - Myositis/virology
MH  - Polymyositis/*etiology
MH  - Prednisolone/pharmacology
MH  - Time Factors
EDAT- 2004/06/16 05:00
MHDA- 2005/01/14 09:00
CRDT- 2004/06/16 05:00
PHST- 2004/06/16 05:00 [pubmed]
PHST- 2005/01/14 09:00 [medline]
PHST- 2004/06/16 05:00 [entrez]
AID - S1600-6135(22)07576-1 [pii]
AID - 10.1111/j.1600-6143.2004.00489.x [doi]
PST - ppublish
SO  - Am J Transplant. 2004 Jul;4(7):1204-7. doi: 10.1111/j.1600-6143.2004.00489.x.