PMID- 15196600
OWN - NLM
STAT- MEDLINE
DCOM- 20041026
LR  - 20200109
IS  - 0924-9338 (Print)
IS  - 0924-9338 (Linking)
VI  - 19
IP  - 4
DP  - 2004 Jun
TI  - Psychosocial functioning in patients with treatment resistant depression.
PG  - 196-201
AB  - BACKGROUND: Depression is a disorder that causes disability, with a profound 
      adverse impact on all areas of psychosocial functioning. This is particularly 
      true for those with treatment resistant depression (TRD). However, to date, no 
      systematic assessments of psychosocial functioning for patients with TRD have 
      been conducted. METHODS: In the present study, we used the Longitudinal Interval 
      Follow-up Evaluation (LIFE) scale to measure psychosocial functioning in 92 
      patients with TRD. These patients met formal criteria for TRD and were part of a 
      clinical trial examining the efficacy of lithium augmentation of nortriptyline. 
      RESULTS: Clinicians rated this sample of patients as experiencing mild to 
      moderate impairment in work-related activities, good to fair interpersonal 
      relations, poor level of involvement in recreational activities, and mild 
      impairment of ability to enjoy sexual activity. Patients and clinicians rated 
      global social adjustment as poor. CONCLUSIONS: Patients with formally defined TRD 
      experience significant impairment in psychosocial functioning. In this sample a 
      tendency existed for both clinicians and patients to assign more severely 
      impaired global ratings when compared with ratings for specific functional areas.
FAU - Petersen, Timothy
AU  - Petersen T
AD  - Department of Psychiatry, Depression Clinical and Research Program, Massachusetts 
      General Hospital, 15 Parkman Street, WAC 812 Boston, MA 02114, USA. 
      tpetersen@partners.org
FAU - Papakostas, George I
AU  - Papakostas GI
FAU - Mahal, Yasmin
AU  - Mahal Y
FAU - Guyker, Wendy M
AU  - Guyker WM
FAU - Beaumont, Erin C
AU  - Beaumont EC
FAU - Alpert, Jonathan E
AU  - Alpert JE
FAU - Fava, Maurizio
AU  - Fava M
FAU - Nierenberg, Andrew A
AU  - Nierenberg AA
LA  - eng
GR  - R29 MH 46952/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Eur Psychiatry
JT  - European psychiatry : the journal of the Association of European Psychiatrists
JID - 9111820
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antidepressive Agents/*therapeutic use
MH  - Depression/*drug therapy/*psychology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Interpersonal Relations
MH  - Male
MH  - Middle Aged
MH  - Sexual Behavior/psychology
MH  - Treatment Failure
EDAT- 2004/06/16 05:00
MHDA- 2004/10/27 09:00
CRDT- 2004/06/16 05:00
PHST- 2003/03/15 00:00 [received]
PHST- 2003/10/24 00:00 [revised]
PHST- 2003/11/20 00:00 [accepted]
PHST- 2004/06/16 05:00 [pubmed]
PHST- 2004/10/27 09:00 [medline]
PHST- 2004/06/16 05:00 [entrez]
AID - S0924933804000616 [pii]
AID - 10.1016/j.eurpsy.2003.11.006 [doi]
PST - ppublish
SO  - Eur Psychiatry. 2004 Jun;19(4):196-201. doi: 10.1016/j.eurpsy.2003.11.006.