PMID- 15202116
OWN - NLM
STAT- MEDLINE
DCOM- 20050201
LR  - 20191114
IS  - 0887-8013 (Print)
IS  - 1098-2825 (Electronic)
IS  - 0887-8013 (Linking)
VI  - 18
IP  - 4
DP  - 2004
TI  - Beta-trace protein, a new marker of GFR, may predict the early prognostic stages 
      of patients with type 2 diabetic nephropathy.
PG  - 237-9
AB  - The relationship between serum levels of beta-trace protein (BTP) or serum 
      creatinine (s-Cr) and the prognostic stages of type 2 diabetic nephropathy was 
      determined. Serum samples from 174 patients with type 2 diabetes were obtained 
      from Juntendo University Hospital, Tokyo, and Juntendo Urayasu Hospital, Chiba, 
      Japan. They were classified into four groups according to the Report of the 
      Ministry of Health and Welfare of Japan (1991, p 251-256) as follows: Stage I 
      (normoalbuminuric stage), Stage II (microalbuminuric stage), Stage IIIA 
      (macroalbuminuric stage without renal dysfunction), Stage IIIB (macroalbuminuric 
      stage with renal dysfunction), and Stage IV (renal failure stage). Among these 
      patients, 68 were Stage I, 29 Stage II, 32 Stage IIIA, 17 Stage IIIB, and 28 
      Stage IV. Levels of serum BTP were measured using the nephelometric assay on a 
      BNA II analyzer (Dade Behring Diagnostics, Marburg, Germany). The mean levels of 
      serum BTP in Stage IIIA were significantly higher than those in Stage I or II (P 
      < 0.00001, P < 0.002, respectively). However, the mean levels of s-Cr in Stage 
      IIIA were not significantly higher than that in Stage I or II. In conclusion, 
      serum BTP was a good marker for the identification of early renal impairment in 
      type 2 diabetes.
CI  - Copyright 2004 Wiley-Liss, Inc.
FAU - Kobata, Mami
AU  - Kobata M
AD  - Division of Nephrology, Department of Internal Medicine, Juntendo University 
      School of Medicine,Tokyo, Japan.
FAU - Shimizu, Ayumi
AU  - Shimizu A
FAU - Rinno, Hisaki
AU  - Rinno H
FAU - Hamada, Chieko
AU  - Hamada C
FAU - Maeda, Kunimi
AU  - Maeda K
FAU - Fukui, Mitsumine
AU  - Fukui M
FAU - Saito, Kensuke
AU  - Saito K
FAU - Horikoshi, Satoshi
AU  - Horikoshi S
FAU - Tomino, Yasuhiko
AU  - Tomino Y
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Lab Anal
JT  - Journal of clinical laboratory analysis
JID - 8801384
RN  - 0 (Biomarkers)
RN  - 0 (Lipocalins)
RN  - AYI8EX34EU (Creatinine)
RN  - EC 5.3.- (Intramolecular Oxidoreductases)
RN  - EC 5.3.99.2 (prostaglandin R2 D-isomerase)
SB  - IM
MH  - Biomarkers/*blood
MH  - Creatinine/blood
MH  - Diabetes Mellitus, Type 2/*diagnosis
MH  - Diabetic Nephropathies/*diagnosis
MH  - *Glomerular Filtration Rate
MH  - Humans
MH  - Intramolecular Oxidoreductases/*blood
MH  - Lipocalins
MH  - Nephelometry and Turbidimetry
MH  - Prognosis
PMC - PMC6807906
EDAT- 2004/06/18 05:00
MHDA- 2005/02/03 09:00
PMCR- 2004/06/11
CRDT- 2004/06/18 05:00
PHST- 2004/06/18 05:00 [pubmed]
PHST- 2005/02/03 09:00 [medline]
PHST- 2004/06/18 05:00 [entrez]
PHST- 2004/06/11 00:00 [pmc-release]
AID - JCLA20029 [pii]
AID - 10.1002/jcla.20029 [doi]
PST - ppublish
SO  - J Clin Lab Anal. 2004;18(4):237-9. doi: 10.1002/jcla.20029.