PMID- 15202792 OWN - NLM STAT- MEDLINE DCOM- 20050118 LR - 20191210 IS - 1434-6621 (Print) IS - 1434-6621 (Linking) VI - 42 IP - 5 DP - 2004 May TI - Amphetamines and 3,4-methylendioxymetamphetamine (MDMA): evaluation of KIMS (kinetic interaction of microparticles in solution) assay at two cut-off levels. PG - 543-8 AB - Two screening methods for the assay of amphetamines and their derivatives have been applied to the same analytical instrument for their evaluation. In addition to an assay at a cut-off of 1000 microg/l, a new specific reagent was evaluated for an ultra-sensitive assay of amphetamines and 3,4-methylendioxymetamphetamine with a cut-off of 300 microg/l. The assay confirmation was performed using high-performance liquid chromatography and gas chromatography/ mass spectrometry techniques. The results were positive for both screening methods, confirming the efficacy of two simultaneous methods with different cut-off levels. FAU - Marchioro, Lucio AU - Marchioro L AD - Department of Laboratory Medicine, University-Hospital of Padova, Padova, Italy. FAU - Bassetto, Flavia AU - Bassetto F FAU - Dall'Olio, Giuliano AU - Dall'Olio G FAU - Tedeschi, Luciano AU - Tedeschi L FAU - Castagna, Franca AU - Castagna F FAU - Plebani, Mario AU - Plebani M LA - eng PT - Comparative Study PT - Evaluation Study PT - Journal Article PL - Germany TA - Clin Chem Lab Med JT - Clinical chemistry and laboratory medicine JID - 9806306 RN - 0 (Amphetamines) RN - 44RAL3456C (Methamphetamine) RN - 4764-17-4 (3,4-Methylenedioxyamphetamine) RN - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine) SB - IM MH - 3,4-Methylenedioxyamphetamine/urine MH - Adolescent MH - Adult MH - Amphetamines/*urine MH - Chromatography, High Pressure Liquid MH - Clinical Chemistry Tests/*methods/statistics & numerical data MH - Enzyme Multiplied Immunoassay Technique/statistics & numerical data MH - Female MH - Gas Chromatography-Mass Spectrometry MH - Humans MH - Immunoassay/*methods/statistics & numerical data MH - Male MH - Methamphetamine/urine MH - Middle Aged MH - N-Methyl-3,4-methylenedioxyamphetamine/*urine MH - Nanostructures MH - Predictive Value of Tests MH - Sensitivity and Specificity MH - Substance-Related Disorders/diagnosis/urine EDAT- 2004/06/19 05:00 MHDA- 2005/01/19 09:00 CRDT- 2004/06/19 05:00 PHST- 2004/06/19 05:00 [pubmed] PHST- 2005/01/19 09:00 [medline] PHST- 2004/06/19 05:00 [entrez] AID - 10.1515/CCLM.2004.092 [doi] PST - ppublish SO - Clin Chem Lab Med. 2004 May;42(5):543-8. doi: 10.1515/CCLM.2004.092.