PMID- 15203176
OWN - NLM
STAT- MEDLINE
DCOM- 20040823
LR  - 20131121
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 26
IP  - 4
DP  - 2004 Jul-Aug
TI  - Spatial acquisition in the Morris water maze and hippocampal long-term 
      potentiation in the adult guinea pig following brain growth spurt--prenatal 
      ethanol exposure.
PG  - 543-51
AB  - Previous work has demonstrated that in the guinea pig, chronic prenatal ethanol 
      exposure throughout gestation can result in deficits in spatial learning in the 
      Morris water maze and impaired hippocampal long-term potentiation (LTP). The 
      behavioural effects are known to be dose dependent because water maze deficits 
      occur at a dose of 4 g ethanol/kg maternal body weight/day, but not at a dose of 
      3 g/kg/day, administered throughout gestation. It is possible that the gradual, 
      progressive development of tolerance to ethanol throughout gestation limits 
      ethanol toxicity, especially for lower doses of ethanol. The present study 
      examined whether neurobehavioural deficits are produced by prenatal ethanol 
      exposure at a dose of 3 g/kg/day, administered only during the brain growth spurt 
      (BGS), a regimen designed to limit the development of ethanol tolerance. Pregnant 
      guinea pigs [term, about gestational day (GD) 68] received oral administration of 
      ethanol (1.5 g/kg maternal body weight/day on GD 43 and 44 and then 3 g/kg 
      maternal body weight/day from GD 45 to 62), isocaloric-sucrose/pair-feeding, or 
      water. Offsprings were studied between postnatal days (PD) 40 and 80. The 
      maternal blood ethanol concentration (BEC) on GD 57 or 58, at 1 h after the daily 
      dose, was 245+/-19 mg/dl (n=7). This BGS--prenatal ethanol exposure regimen did 
      not affect spatial learning performance in the Morris water maze over a 7-day 
      test period or in the LTP recorded in the CA1 region of the hippocampus. Thus, 
      even when limiting the development of ethanol tolerance seen with chronic ethanol 
      treatment throughout gestation, ethanol exposure during the BGS does not result 
      in deficits in the behavioural and electrophysiological measures of hippocampal 
      integrity assessed in the present study. These data indicate that in the guinea 
      pig, the BGS may not constitute a critical period of vulnerability for 
      ethanol-induced deficits in spatial learning or hippocampal synaptic plasticity 
      in young adult offspring.
CI  - Copyright 2004 Elsevier Inc.
FAU - Byrnes, M L
AU  - Byrnes ML
AD  - Department of Pharmacology and Toxicology, Queen's University, Kingston, ON, 
      Canada K7L 3N6.
FAU - Richardson, D P
AU  - Richardson DP
FAU - Brien, J F
AU  - Brien JF
FAU - Reynolds, J N
AU  - Reynolds JN
FAU - Dringenberg, H C
AU  - Dringenberg HC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Animals
MH  - Drug Administration Schedule
MH  - Escape Reaction/drug effects
MH  - Ethanol/blood/*pharmacology
MH  - Excitatory Postsynaptic Potentials/drug effects
MH  - Female
MH  - Guinea Pigs
MH  - Hippocampus/*drug effects/embryology/physiopathology
MH  - Long-Term Potentiation/*drug effects
MH  - Male
MH  - Maze Learning/*drug effects
MH  - Organ Size/drug effects
MH  - Pregnancy
MH  - Pregnancy Complications/chemically induced/physiopathology
MH  - *Prenatal Exposure Delayed Effects
MH  - Spatial Behavior/*drug effects
MH  - Time Factors
EDAT- 2004/06/19 05:00
MHDA- 2004/08/24 05:00
CRDT- 2004/06/19 05:00
PHST- 2004/01/16 00:00 [received]
PHST- 2004/04/06 00:00 [revised]
PHST- 2004/04/07 00:00 [accepted]
PHST- 2004/06/19 05:00 [pubmed]
PHST- 2004/08/24 05:00 [medline]
PHST- 2004/06/19 05:00 [entrez]
AID - S0892036204000650 [pii]
AID - 10.1016/j.ntt.2004.04.005 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2004 Jul-Aug;26(4):543-51. doi: 10.1016/j.ntt.2004.04.005.