PMID- 15203179
OWN - NLM
STAT- MEDLINE
DCOM- 20040823
LR  - 20131121
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 26
IP  - 4
DP  - 2004 Jul-Aug
TI  - The relationship between hyperthermia and glycogenolysis in 
      3,4-methylenedioxymethamphetamine-induced serotonin depletion in rats.
PG  - 571-7
AB  - Although the exact mechanisms involved in the serotonergic neurotoxicity produced 
      by substituted amphetamines are not completely known, evidence suggests that 
      oxidative and/or bioenergetic stress may contribute in the mechanism of 
      neurotoxicity of 3,4-methylenedioxymethamphetamine (MDMA). It has been postulated 
      that MDMA-induced hyperthermia also contributes to the MDMA-induced 
      neurotoxicity. MDMA produces brain glycogenolysis, and MDMA-induced hyperthermia 
      appears to mediate this effect. The relationship of MDMA-induced hyperthermia and 
      glycogenolysis in the serotonergic neurotoxicity of MDMA was investigated in the 
      present study. The administration of MDMA (20 mg/kg sc) at an ambient temperature 
      of 24 degrees C produced hyperthermia and brain glycogenolysis in Postnatal Day 
      (PND)21 and PND70 rats; however, long-term reductions in serotonin (5-HT) 
      concentrations in the striatum were detected only in the PND70 rats. Treatment of 
      PND21 and PND70 rats with MDMA at 17 degrees C resulted in neither hyperthermia 
      nor glycogenolysis; nevertheless, long-term reductions in 5-HT concentrations 
      were still evident in the PND70 rats treated with MDMA. These results support the 
      conclusion that hyperthermia, as well as glycogenolysis, are neither necessary 
      nor sufficient in the serotonergic neurotoxicity of MDMA.
CI  - Copyright 2004 Elsevier Inc.
FAU - Darvesh, Altaf S
AU  - Darvesh AS
AD  - College of Pharmacy, University of Cincinnati, 3223 Eden Ave., Cincinnati, OH 
      45267, USA.
FAU - Gudelsky, Gary A
AU  - Gudelsky GA
LA  - eng
GR  - DA07427/DA/NIDA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Serotonin Agents)
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Animals, Newborn
MH  - Body Temperature/drug effects/physiology
MH  - Body Temperature Regulation/physiology
MH  - Brain/drug effects/metabolism
MH  - Brain Chemistry
MH  - Fever/*metabolism
MH  - Glycogen Storage Disease/*metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*deficiency
MH  - Serotonin Agents/*pharmacology
EDAT- 2004/06/19 05:00
MHDA- 2004/08/24 05:00
CRDT- 2004/06/19 05:00
PHST- 2004/01/14 00:00 [received]
PHST- 2004/03/23 00:00 [revised]
PHST- 2004/03/25 00:00 [accepted]
PHST- 2004/06/19 05:00 [pubmed]
PHST- 2004/08/24 05:00 [medline]
PHST- 2004/06/19 05:00 [entrez]
AID - S0892036204000509 [pii]
AID - 10.1016/j.ntt.2004.03.008 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2004 Jul-Aug;26(4):571-7. doi: 10.1016/j.ntt.2004.03.008.