PMID- 15203564
OWN - NLM
STAT- MEDLINE
DCOM- 20041116
LR  - 20181113
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 13
IP  - 1
DP  - 2004 Feb
TI  - Monocyte chemoattractant protein-1 in patients with peripheral arterial disease.
PG  - 39-43
AB  - BACKGROUND: Chemokine-driven migration of inflammatory cells has been implicated 
      in the pathogenesis of atherosclerotic conditions including peripheral arterial 
      disease (PAD). Monocyte chemoattractant protein-1 (MCP-1) is elevated in patients 
      with coronary artery disease and in hypertensive patients. This study therefore 
      investigated MCP-1 in patients with PAD. METHODS: Serum MCP-1 was determined by 
      enzyme-linked immunosorbent assay in 36 healthy, control subjects and in 19 
      patients with PAD. Statistical analysis utilised the Mann-Whitney test and 
      Spearman correlation (p < 0.05). RESULTS: MCP-1 (pg/ml) was increased in patients 
      compared with in controls (mean+/-standard error of the mean: PAD group, 
      748+/-60; control group, 459+/-27; p=0.0001). MCP-1 levels tended to decrease 
      with progressing disease. From atherosclerosis risk factors, diabetes inclined to 
      increase MCP-1 levels; hypertension had no effect. Serum MCP-1 correlated with 
      cholesterol, triglycerides, low-density lipoprotein but not high-density 
      lipoprotein. CONCLUSION: Elevation of MCP-1 in the circulation of PAD patients 
      shown in the present pilot study implicates this CC chemokine ligand 2 in 
      inflammatory processes contributing to PAD clinical symptomatology. Further 
      investigations are necessary to evaluate whether MCP-1 can be used as a potential 
      marker of peripheral arterial disease follow-up and/or prognosis.
FAU - Petrkova, Jana
AU  - Petrkova J
AD  - Department of Immunology, Palacky University and Faculty Hospital, Olomouc, Czech 
      Republic.
FAU - Szotkowska, Jaroslava
AU  - Szotkowska J
FAU - Hermanova, Zuzana
AU  - Hermanova Z
FAU - Lukl, Jan
AU  - Lukl J
FAU - Petrek, Martin
AU  - Petrek M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Lipids)
SB  - IM
MH  - Aged
MH  - *Arteries
MH  - Arteriosclerosis/etiology
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Chemokine CCL2/*blood
MH  - Diabetes Complications
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Hypertension/complications
MH  - Immunoassay
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Peripheral Vascular Diseases/*blood/complications
MH  - Pilot Projects
MH  - Risk Factors
MH  - Smoking/adverse effects
PMC - PMC1781535
EDAT- 2004/06/19 05:00
MHDA- 2004/11/17 09:00
PMCR- 2004/02/01
CRDT- 2004/06/19 05:00
PHST- 2004/06/19 05:00 [pubmed]
PHST- 2004/11/17 09:00 [medline]
PHST- 2004/06/19 05:00 [entrez]
PHST- 2004/02/01 00:00 [pmc-release]
AID - 9R1FUG1P3ATM7EKH [pii]
AID - 10.1080/09629350410001664752 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2004 Feb;13(1):39-43. doi: 10.1080/09629350410001664752.