PMID- 15204767
OWN - NLM
STAT- MEDLINE
DCOM- 20040720
LR  - 20191026
IS  - 0895-8378 (Print)
IS  - 0895-8378 (Linking)
VI  - 16
IP  - 4
DP  - 2004 Apr
TI  - Exhaled ethanol and acetaldehyde in human subjects exposed to low levels of 
      ethanol.
PG  - 203-7
AB  - With the increased use of ethanol-blend gasoline as an alternative to gasoline, 
      there is a demand for new data to assess the potential health risk of ethanol 
      exposure. Currently, there is very limited information from the scientific 
      database on the adverse effects of inhaled low doses of ethanol (ETOH). The aim 
      of this study was to determine the concentration of ETOH and acetaldehyde 
      (ACTDH), a toxic metabolite of ETOH, in the alveolar air (AA) of subjects exposed 
      to low ETOH vapor concentrations by inhalation. Five healthy adults (2 women, 3 
      men), nonsmoking, 25-55 yr of age, were exposed for 6 consecutive hours to 25, 
      100, or 1000 ppm ETOH and were asked to provide AA samples at various intervals 
      during and after each exposure session, for ETOH and ACTDH measurements. Results 
      showed that the concentrations of ACTDH and ETOH in AA measured after 2 h of 
      exposure at 25 ppm were 0.06 ppm and 7.5 ppm, respectively. Overall, there was a 
      significant correlation between ETOH exposure and ETOH (R(2) =.92, p <.001) and 
      ACTDH (R(2) =.99, p <.001) in AA. The ratios between ACTDH and ETOH in AA after 4 
      h of exposure to 25.9 ppm, 101.7 ppm, and 990.8 ppm ETOH were 0.005, 0.008, and 
      0.006, respectively. In conclusion, this study showed that inhalation of ETOH at 
      low concentrations resulted in measurable levels of ACTDH in AA and suggests that 
      ACTDH may be used, with good toxicological relevance, as an indicator of exposure 
      to low levels of ETOH in air.
FAU - Tardif, Robert
AU  - Tardif R
AD  - Department of Occupational and Environmental Health, University of Montreal, 
      Montreal, Quebec, Canada. robert.tardif@umontreal.ca
FAU - Liu, Ling
AU  - Liu L
FAU - Raizenne, Mark
AU  - Raizenne M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Inhal Toxicol
JT  - Inhalation toxicology
JID - 8910739
RN  - 0 (Air Pollutants)
RN  - 0 (Biomarkers)
RN  - 3K9958V90M (Ethanol)
RN  - GO1N1ZPR3B (Acetaldehyde)
SB  - IM
MH  - Acetaldehyde/analysis/*metabolism
MH  - Adult
MH  - Air Pollutants/analysis/*pharmacokinetics
MH  - Biomarkers/analysis
MH  - Breath Tests
MH  - Dose-Response Relationship, Drug
MH  - Ethanol/administration & dosage/analysis/*pharmacokinetics
MH  - Exhalation/physiology
MH  - Female
MH  - Humans
MH  - Inhalation Exposure
MH  - Male
MH  - Middle Aged
EDAT- 2004/06/19 05:00
MHDA- 2004/07/21 05:00
CRDT- 2004/06/19 05:00
PHST- 2004/06/19 05:00 [pubmed]
PHST- 2004/07/21 05:00 [medline]
PHST- 2004/06/19 05:00 [entrez]
AID - 285G8HTTEWLAXLUA [pii]
AID - 10.1080/08958370490277272 [doi]
PST - ppublish
SO  - Inhal Toxicol. 2004 Apr;16(4):203-7. doi: 10.1080/08958370490277272.