PMID- 1520508
OWN - NLM
STAT- MEDLINE
DCOM- 19921015
LR  - 20180222
IS  - 0029-0831 (Print)
IS  - 0029-0831 (Linking)
VI  - 24
IP  - 4
DP  - 1992 Jul
TI  - [Development of human cerebellar granular layer: a morphometric study].
PG  - 327-34
AB  - Development of the cerebellar granular layer, the external granular layer (EGL) 
      and the internal granular layer (IGL), was studied morphologically to make 
      complete serial sections of the brain from human fetuses ranging 12 to 40 weeks' 
      gestation (WG). To examine the chronological changes and the regional 
      differences, we measured the thickness of the layer microscopically among five 
      different parts of the cerebellum: anterior lobe/hemisphere (AH), anterior 
      lobe/vermis (AV), posterior lobe/hemisphere (PH), posterior lobe/vermis (PV) and 
      flocculus (FL). EGL was the most superficial layer composed of densely packed 
      undifferentiated cells. Its thickness showed little changes during the fetal 
      period of 12-40 WG for all parts except FL where EGL was thicker than those in 
      other parts and made a gradual attenuation with development. We noticed at least 
      three stages in the fetal development of IGL: 1) the primary or undifferentiated 
      stage (before 18 WG) when IGL was hardly distinguishable from the layer of 
      immature Purkinje cells (PCL); 2) the secondary or intermediate stage (18 to 30 
      or 35 WG) when it was clearly visible and almost stable in thickness for all 
      parts; 3) the tertiary or developing stage (30 or 35 to 40 WG) when it showed a 
      dramatic increase in thickness as the formation of cerebellar folia was 
      proceeding. During the intermediate stage the Lamina dissecans was observed 
      between PCL and IGL typically in PH. Regional differences were detected in a 
      period of transition from the intermediate to the developing stage among each 
      part: the developing stage appeared earliest in AV and FL and latest in 
      PH.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Yamaguchi, K
AU  - Yamaguchi K
AD  - Department of Pediatrics, Higashi-Saitama National Hospital.
FAU - Goto, N
AU  - Goto N
FAU - Nara, T
AU  - Nara T
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - No To Hattatsu
JT  - No to hattatsu = Brain and development
JID - 0215224
SB  - IM
MH  - Cerebellum/*embryology/ultrastructure
MH  - Child, Preschool
MH  - Gestational Age
MH  - Humans
MH  - Microscopy
MH  - Middle Aged
EDAT- 1992/07/01 00:00
MHDA- 1992/07/01 00:01
CRDT- 1992/07/01 00:00
PHST- 1992/07/01 00:00 [pubmed]
PHST- 1992/07/01 00:01 [medline]
PHST- 1992/07/01 00:00 [entrez]
PST - ppublish
SO  - No To Hattatsu. 1992 Jul;24(4):327-34.