PMID- 15205565
OWN - NLM
STAT- MEDLINE
DCOM- 20050623
LR  - 20151119
IS  - 0378-7346 (Print)
IS  - 0378-7346 (Linking)
VI  - 58
IP  - 3
DP  - 2004
TI  - Hyperhomocyst(e)inemia and elevated soluble vascular cell adhesion molecule-1 
      concentrations are associated with an increased risk of preeclampsia.
PG  - 133-9
AB  - Hyperhomocyst(e)inemia (HHcy) is a risk factor of endothelial dysfunction and 
      preeclampsia. Soluble vascular cell adhesion molecule-1 (sVCAM-1), a specific 
      marker of endothelial dysfunction, is elevated in preeclampsia. Few have assessed 
      the joint contribution of these biomarkers in predicting preeclampsia. We 
      assessed the extent to which HHcy and elevated sVCAM-1 are independently and 
      jointly associated with preeclampsia. We conducted a case-control analysis of 100 
      preeclampsia cases and 100 controls to test our study hypothesis. Maternal plasma 
      was collected before labor onset. Total plasma homocysteine (tHcy) was measured 
      using high-performance liquid chromatography with electrochemical detection 
      procedures. Plasma sVCAM-1 was determined using ELISA. Using the distribution of 
      each analyte among controls, elevated tHcy was defined as plasma tHcy >6.6 
      micromol/l and elevated sVCAM-1 was defined as plasma concentrations >845 ng/ml 
      (i.e., values above the median). Odds ratios (OR) and 95% confidence intervals 
      (CIs) were calculated. Compared with women without elevated tHcy and without 
      elevated sVCAM-1 (the referent group), those with elevated sVCAM-1 alone had a 
      4.1-fold increased risk of preeclampsia (95% CI 1.2-13.8). The OR for women with 
      elevated tHcy alone was 2.2 (95% CI 0.6-7.9). The OR for women with elevated tHcy 
      and sVCAM-1 was 13.2 (95% CI 4.1-42.2). Elevated tHcy and sVCAM-1 together were 
      strongly associated with an increased risk of preeclampsia. Larger, prospective 
      studies are needed to confirm these findings and to determine the extent to which 
      elevated tHcy and sVCAM-1 together in early pregnancy are predictive of 
      preeclampsia risk.
CI  - Copyright (c) 2004 S. Karger AG, Basel.
FAU - Vadachkoria, Surab
AU  - Vadachkoria S
AD  - Center for Perinatal Studies, Swedish Medical Center, Seattle, WA 98122, USA. 
      Surab.Vadachkoria@Swedish.org
FAU - Sanchez, Sixto E
AU  - Sanchez SE
FAU - Qiu, Chunfang
AU  - Qiu C
FAU - Muy-Rivera, Martin
AU  - Muy-Rivera M
FAU - Malinow, M Rene
AU  - Malinow MR
FAU - Williams, Michelle A
AU  - Williams MA
LA  - eng
GR  - R01-32562/PHS HHS/United States
GR  - R03-TW01159/TW/FIC NIH HHS/United States
GR  - R40 MC 00186/PHS HHS/United States
GR  - RR-00163/RR/NCRR NIH HHS/United States
GR  - T37-TW00049/TW/FIC NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20040614
PL  - Switzerland
TA  - Gynecol Obstet Invest
JT  - Gynecologic and obstetric investigation
JID - 7900587
RN  - 0 (Biomarkers)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Female
MH  - Homocysteine/*biosynthesis
MH  - Humans
MH  - Hyperhomocysteinemia/*blood
MH  - Odds Ratio
MH  - Pre-Eclampsia/*blood/epidemiology
MH  - Pregnancy
MH  - Risk Factors
MH  - Vascular Cell Adhesion Molecule-1/*biosynthesis/blood
EDAT- 2004/06/19 05:00
MHDA- 2005/06/24 09:00
CRDT- 2004/06/19 05:00
PHST- 2003/09/30 00:00 [received]
PHST- 2004/03/22 00:00 [accepted]
PHST- 2004/06/19 05:00 [pubmed]
PHST- 2005/06/24 09:00 [medline]
PHST- 2004/06/19 05:00 [entrez]
AID - 79067 [pii]
AID - 10.1159/000079067 [doi]
PST - ppublish
SO  - Gynecol Obstet Invest. 2004;58(3):133-9. doi: 10.1159/000079067. Epub 2004 Jun 
      14.