PMID- 15206018
OWN - NLM
STAT- MEDLINE
DCOM- 20040818
LR  - 20181113
IS  - 0932-433X (Print)
IS  - 0932-433X (Linking)
VI  - 18
IP  - 3
DP  - 2004 Jun
TI  - [Visual cortex in the Tolosa-Hunt syndrome. Functional imaging for the detection 
      of a psychogenic disorder--a case report].
PG  - 211-7
AB  - Besides painful ophthalmoplegia, patients suffering from Tolosa-Hunt syndrome 
      often present increasing loss of visual perception. The impairment of the optic 
      nerve leads to a delay of the VEP (visual evoked potentials) responses. Using the 
      method of magnetic resonance imaging (MRI), some patients present unspecific 
      alterations in the vicinity of the optic nerve. However, both methods (VEP and 
      MRI) are unsuitable to assess the effect of an impaired optic nerve function on 
      neuronal processing in the visual cortex. We report one patient suffering from 
      Tolosa-Hunt syndrome affecting the optic nerve. We used fMRI (functional magnetic 
      resonance imaging) to show how this impairment of the optic nerve alters cortical 
      processing of visual information. The activity of the unaffected visual cortex 
      was bilaterally reduced when compared to healthy volunteers but greater that 
      obtained from patients suffering from bilateral occipital infarction. Our results 
      offer new opportunities to assess the efficiency of therapy in patients with 
      increasing loss of visual perception due to the Tolosa-Hunt syndrome. Further 
      studies are necessary to investigate, whether fMRI also provides the possibility 
      to assess the efficiency of drug therapy on optic nerve function.
FAU - Pleger, B
AU  - Pleger B
AD  - Klinik fur Neurologie, BG-Kliniken Bergmannsheil, Universitatsklinik der 
      Ruhr-Universitat Bochum. burkhard.v.pleger@ruhr-uni-bochum.de
FAU - Forster, A-F
AU  - Forster AF
FAU - Schwenkreis, P
AU  - Schwenkreis P
FAU - Nicolas, V
AU  - Nicolas V
FAU - Malin, J-P
AU  - Malin JP
FAU - Frettloh, J
AU  - Frettloh J
FAU - Maier, C
AU  - Maier C
FAU - Tegenthoff, M
AU  - Tegenthoff M
LA  - ger
PT  - Case Reports
PT  - English Abstract
PT  - Journal Article
TT  - Visusstorungen beim Tolosa-Hunt-Syndrom. Untersuchung mit der funktionellen 
      Magnetresonanztomographie zur Abgrenzung psychogener Storungen--Ein Fallbericht.
PL  - Germany
TA  - Schmerz
JT  - Schmerz (Berlin, Germany)
JID - 8906258
SB  - IM
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Optic Nerve/pathology/physiopathology
MH  - Tolosa-Hunt Syndrome/diagnosis/*physiopathology/psychology
MH  - Visual Cortex/pathology/*physiopathology
EDAT- 2004/06/19 05:00
MHDA- 2004/08/19 05:00
CRDT- 2004/06/19 05:00
PHST- 2004/06/19 05:00 [pubmed]
PHST- 2004/08/19 05:00 [medline]
PHST- 2004/06/19 05:00 [entrez]
AID - 10.1007/s00482-004-0309-3 [doi]
PST - ppublish
SO  - Schmerz. 2004 Jun;18(3):211-7. doi: 10.1007/s00482-004-0309-3.