PMID- 15206020
OWN - NLM
STAT- MEDLINE
DCOM- 20050426
LR  - 20220408
IS  - 0931-041X (Print)
IS  - 0931-041X (Linking)
VI  - 19
IP  - 8
DP  - 2004 Aug
TI  - Effects of pentoxifylline in adriamycin-induced renal disease in rats.
PG  - 840-3
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a mediator of inflammation in human 
      and animal renal disease. Pentoxiphylline (PTX) is an inhibitor of TNF-alpha. In 
      this study we examined the effects of PTX on TNF-alpha, proteinuria, nitrite 
      production, and apoptosis in an experimental model of Adriamycin (ADR) 
      nephropathy in rats. Rats were divided into four groups: untreated Wistar rats 
      (controls), PTX treatment alone, ADR treatment alone to induce nephropathy, and 
      ADR treatment followed by PTX. ADR treatment followed by PTX treatment prevented 
      the increase in serum TNF-alpha levels and proteinuria in rats with 
      ADR-nephropathy ( P<0.05). Urine nitrite levels were significantly increased in 
      the ADR-induced nephropathy group and the increase was prevented in the 
      ADR-induced nephropathy group when they also received PTX. The urine nitrite 
      levels were not different between the PTX-treated group and the untreated control 
      rats. PTX prevented the rise of serum TNF-alpha in ADR nephropathy rats and a 
      decrease in proteinuria, urine nitrite, and apoptosis in the renal tissue. These 
      findings suggest a beneficial anti-inflammatory effect of PTX.
FAU - Usta, Yusuf
AU  - Usta Y
AD  - Department of Pediatrics, Faculty of Medicine, Hacettepe University, Sihhiye 
      06100, Ankara, Turkey.
FAU - Ismailoglu, Ugur Burcin
AU  - Ismailoglu UB
FAU - Bakkaloglu, Aysin
AU  - Bakkaloglu A
FAU - Orhan, Dicle
AU  - Orhan D
FAU - Besbas, Nesrin
AU  - Besbas N
FAU - Sahin-Erdemli, Inci
AU  - Sahin-Erdemli I
FAU - Ozen, Seza
AU  - Ozen S
LA  - eng
PT  - Journal Article
DEP - 20040616
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 80168379AG (Doxorubicin)
RN  - SD6QCT3TSU (Pentoxifylline)
SB  - IM
MH  - Animals
MH  - Apoptosis/*drug effects
MH  - *Doxorubicin/administration & dosage
MH  - Kidney Diseases/chemically induced/*metabolism
MH  - Pentoxifylline/*pharmacology
MH  - Proteinuria/*chemically induced
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/*analysis/*antagonists & inhibitors
EDAT- 2004/06/19 05:00
MHDA- 2005/04/27 09:00
CRDT- 2004/06/19 05:00
PHST- 2003/12/01 00:00 [received]
PHST- 2004/04/22 00:00 [revised]
PHST- 2004/04/25 00:00 [accepted]
PHST- 2004/06/19 05:00 [pubmed]
PHST- 2005/04/27 09:00 [medline]
PHST- 2004/06/19 05:00 [entrez]
AID - 10.1007/s00467-004-1538-5 [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2004 Aug;19(8):840-3. doi: 10.1007/s00467-004-1538-5. Epub 2004 
      Jun 16.