PMID- 15207270
OWN - NLM
STAT- MEDLINE
DCOM- 20040818
LR  - 20131121
IS  - 0969-9961 (Print)
IS  - 0969-9961 (Linking)
VI  - 16
IP  - 1
DP  - 2004 Jun
TI  - Increased mortality and spatial memory deficits in TNF-alpha-deficient mice in 
      ceftriaxone-treated experimental pneumococcal meningitis.
PG  - 133-8
AB  - Tumor necrosis factor-alpha (TNF-alpha) is critically involved in inflammation 
      and may participate in hippocampal injury in bacterial meningitis. In a mouse 
      model of ceftriaxone-treated pneumococcal meningitis, spatial memory and motor 
      performance of TNF-alpha-deficient (n = 57) and control mice (n = 55) were 
      investigated. After infection, therapy was initiated with ceftriaxone (100 mg/kg 
      twice daily for 5 days). Sixty-three percent TNF-alpha-deficient mice and 40% 
      control animals died within 6 days (Fisher's exact test: P = 0.02). 
      TNF-alpha-deficient mice surviving pneumococcal meningitis took substantially 
      longer to reach the hidden platform than controls, and the distance of swim 
      tracks was longer (P = 0.02). The swim speed in both groups was similar (P = 
      0.59). The proliferation of dentate granule cells was lower in 
      TNF-alpha-deficient than in wild-type mice (P = 0.03). In pneumococcal 
      meningitis, TNF-alpha deficiency caused increased mortality and stronger deficits 
      in spatial memory possibly due to impaired neurogenesis.
FAU - Gerber, Joachim
AU  - Gerber J
AD  - Department of Neurology, Georg-August-University, Gottingen 37075, Germany.
FAU - Bottcher, Tobias
AU  - Bottcher T
FAU - Hahn, Michael
AU  - Hahn M
FAU - Siemer, Alexander
AU  - Siemer A
FAU - Bunkowski, Stephanie
AU  - Bunkowski S
FAU - Nau, Roland
AU  - Nau R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurobiol Dis
JT  - Neurobiology of disease
JID - 9500169
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 75J73V1629 (Ceftriaxone)
SB  - IM
MH  - Animals
MH  - Ceftriaxone/pharmacology/*therapeutic use
MH  - Hippocampus/drug effects/metabolism
MH  - Maze Learning/drug effects/physiology
MH  - Memory Disorders/genetics/*metabolism/*mortality
MH  - Meningitis, Pneumococcal/*drug therapy/genetics/*metabolism/mortality
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Psychomotor Performance/drug effects/physiology
MH  - Tumor Necrosis Factor-alpha/*deficiency/genetics
EDAT- 2004/06/23 05:00
MHDA- 2004/08/19 05:00
CRDT- 2004/06/23 05:00
PHST- 2003/07/25 00:00 [received]
PHST- 2004/01/16 00:00 [revised]
PHST- 2004/01/16 00:00 [accepted]
PHST- 2004/06/23 05:00 [pubmed]
PHST- 2004/08/19 05:00 [medline]
PHST- 2004/06/23 05:00 [entrez]
AID - S0969996104000221 [pii]
AID - 10.1016/j.nbd.2004.01.013 [doi]
PST - ppublish
SO  - Neurobiol Dis. 2004 Jun;16(1):133-8. doi: 10.1016/j.nbd.2004.01.013.