PMID- 1520878
OWN - NLM
STAT- MEDLINE
DCOM- 19921013
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 80
IP  - 6
DP  - 1992 Sep 15
TI  - Human lymphotropic retroviruses associated with mycosis fungoides: evidence that 
      human T-cell lymphotropic virus type II (HTLV-II) as well as HTLV-I may play a 
      role in the disease.
PG  - 1537-45
AB  - The human T-cell lymphotropic virus type I (HTLV-I) is causally associated with 
      adult T-cell leukemia, but its role in mycosis fungoides (MF) has remained 
      enigmatic. The virus is suspect because a small percentage of patients with MF 
      have antibodies to it, the cells of others harbor deleted HTLV-I proviral 
      sequences, and particles resembling HTLV-I emerge in cultured blood lymphocytes 
      obtained from most patients. An alternative possibility is that disparate 
      lymphotropic retroviruses may infect or affect a population of epidermotropic 
      lymphocytes, leading to the same outcome, ie, MF. In studies designed to identify 
      the particles detected in lymphocyte cultures of nine patients with a diagnosis 
      of skin involvement characteristic of MF, this concept has gained support. While 
      the cells of four patients provided evidence of HTLV-I infection, molecular 
      hybridization with HTLV-II-specific pol probes showed HTLV-II in the cells of 
      another patient. The 103-bp fragment amplified by the HTLV-II-specific probe was 
      sequenced and proved to have greater than 90% homology with the same fragment 
      amplified from cells known to be infected with HTLV-II. A role for HTLV-II in MF 
      has not been suggested heretofore. Therefore, HTLV-I, HTLV-II, and their 
      incomplete forms may be found in cells of MF patients, suggesting new theories 
      regarding the pathogenesis of this disease.
FAU - Zucker-Franklin, D
AU  - Zucker-Franklin D
AD  - Department of Medicine, New York University Medical Center, New York 10016.
FAU - Hooper, W C
AU  - Hooper WC
FAU - Evatt, B L
AU  - Evatt BL
LA  - eng
SI  - GENBANK/S44624
SI  - GENBANK/S44625
SI  - GENBANK/S72766
SI  - GENBANK/S72767
SI  - GENBANK/S72768
SI  - GENBANK/S72769
SI  - GENBANK/S72771
SI  - GENBANK/X63096
SI  - GENBANK/X63097
SI  - GENBANK/X63098
GR  - AM-12274/AM/NIADDK NIH HHS/United States
GR  - HL-42103/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Base Sequence
MH  - DNA, Viral/ultrastructure
MH  - Female
MH  - Human T-lymphotropic virus 1/growth & development/*physiology
MH  - Human T-lymphotropic virus 2/growth & development/*physiology
MH  - Humans
MH  - Lymphocytes/microbiology/ultrastructure
MH  - Middle Aged
MH  - Molecular Sequence Data
MH  - Mycosis Fungoides/*microbiology
MH  - Sequence Homology, Nucleic Acid
EDAT- 1992/09/15 00:00
MHDA- 1992/09/15 00:01
CRDT- 1992/09/15 00:00
PHST- 1992/09/15 00:00 [pubmed]
PHST- 1992/09/15 00:01 [medline]
PHST- 1992/09/15 00:00 [entrez]
AID - S0006-4971(20)67579-6 [pii]
PST - ppublish
SO  - Blood. 1992 Sep 15;80(6):1537-45.