PMID- 15209004
OWN - NLM
STAT- MEDLINE
DCOM- 20040824
LR  - 20061115
IS  - 1000-8020 (Print)
IS  - 1000-8020 (Linking)
VI  - 33
IP  - 2
DP  - 2004 Mar
TI  - [Effects of chronic alcohol administration on the activities of the key 
      glycolytic enzymes of rats].
PG  - 195-7
AB  - In order to study the effects of chronic alcohol administration on the activities 
      of the key glycolytic enzymes, a oral administration of alcohol solution in 
      different concentrations was given to rats for 9 weeks. The activities of 
      glucokinase (GK), phosphofructokinase (PFK) and hexokinase (HK) in liver were 
      determined at the end of the study. The results showed that the activities of GK 
      and PFK in the groups administrated with 30% and 50% alcohol solution decreased 
      obviously in comparison with that in control group (P < 0.05). But the activity 
      of HK had no significant differences in all five groups. Correlation analysis 
      indicated that the activities of GK and PFK were correlated with the dose of 
      alcohol significantly (r = -0.99(-)-0.97, P < 0.05). These results demonstrated 
      that chronic alcohol administration can suppress the glycolytic pathway. They can 
      also be one of the mechanisms of diabetes mellitus relating to alcohol because of 
      the high blood sugar and the disturbed blood sugar regulation.
FAU - Pang, Hong
AU  - Pang H
AD  - Tongji Medical College, Huazhong University of Science and Technology, Wuhan 
      430030, China.
FAU - Zhang, Jun
AU  - Zhang J
FAU - Mao, Limei
AU  - Mao L
FAU - Yang, Nianhong
AU  - Yang N
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Wei Sheng Yan Jiu
JT  - Wei sheng yan jiu = Journal of hygiene research
JID - 9426367
RN  - EC 2.7.1 - (Phosphofructokinases)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 2.7.1.2 (Glucokinase)
SB  - IM
MH  - Alcoholism/*enzymology
MH  - Animals
MH  - Female
MH  - Glucokinase/*metabolism
MH  - Hexokinase/metabolism
MH  - Liver/*enzymology
MH  - Male
MH  - Phosphofructokinases/*metabolism
MH  - Rats
MH  - Rats, Wistar
EDAT- 2004/06/24 05:00
MHDA- 2004/08/25 05:00
CRDT- 2004/06/24 05:00
PHST- 2004/06/24 05:00 [pubmed]
PHST- 2004/08/25 05:00 [medline]
PHST- 2004/06/24 05:00 [entrez]
PST - ppublish
SO  - Wei Sheng Yan Jiu. 2004 Mar;33(2):195-7.