PMID- 15209306
OWN - NLM
STAT- MEDLINE
DCOM- 20040824
LR  - 20041117
IS  - 0031-5125 (Print)
IS  - 0031-5125 (Linking)
VI  - 98
IP  - 3 Pt 1
DP  - 2004 Jun
TI  - Differential effects of laughter on allergen-specific immunoglobulin and 
      neurotrophin levels in tears.
PG  - 901-8
AB  - Laughter after viewing a humorous video "Modern Times" decreased Japanese cedar 
      pollen-specific immunoglobulin E (IgE) and IgG4 levels, while it enhanced 
      Japanese cedar pollen-specific IgA levels in tears of patients with atopic 
      keratoconjunctivitis, while viewing a nonhumorous weather information video did 
      not do so. Laughter after viewing "Modern Times" also decreased nerve growth 
      factor levels without affecting neurotrophin-3 levels in tears of those patients, 
      while viewing a weather information video did not. These results indicate that 
      laughter decreased allergen-specific IgE and IgG4 production and increased 
      allergen-specific IgA production with concomitant decrease in nerve growth 
      factor. These results indicate that laughter may have some implications for study 
      and treatment of allergic diseases.
FAU - Kimata, Hajime
AU  - Kimata H
AD  - Department of Allergy, Ujitakeda Hospital, Uji-City, Kyoto Prefecture, Japan. 
      h-kimata@takedahp.or.jp
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Percept Mot Skills
JT  - Perceptual and motor skills
JID - 0401131
RN  - 0 (Allergens)
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Nerve Growth Factors)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Affect
MH  - Allergens/*metabolism
MH  - Female
MH  - Humans
MH  - Immunoglobulin A/*metabolism
MH  - Immunoglobulin E/*metabolism
MH  - Immunoglobulin G/*metabolism
MH  - *Laughter
MH  - Male
MH  - Nerve Growth Factors/*metabolism
MH  - Tears/*metabolism
EDAT- 2004/06/24 05:00
MHDA- 2004/08/25 05:00
CRDT- 2004/06/24 05:00
PHST- 2004/06/24 05:00 [pubmed]
PHST- 2004/08/25 05:00 [medline]
PHST- 2004/06/24 05:00 [entrez]
AID - 10.2466/pms.98.3.901-908 [doi]
PST - ppublish
SO  - Percept Mot Skills. 2004 Jun;98(3 Pt 1):901-8. doi: 10.2466/pms.98.3.901-908.