PMID- 15209353
OWN - NLM
STAT- MEDLINE
DCOM- 20041215
LR  - 20191108
IS  - 0892-3973 (Print)
IS  - 0892-3973 (Linking)
VI  - 26
IP  - 2
DP  - 2004 May
TI  - Dehydrocostus lactone enhances tumor necrosis factor-alpha-induced apoptosis of 
      human leukemia HL-60 cells.
PG  - 163-75
AB  - Sesquiterpene lactones have raised considerable interest because of their ability 
      to block the activation of nuclear transcription factor-kappaB (NF-kappaB). 
      NF-kappaB plays an important role in the resistance of cancer cells to the 
      induction of apoptosis by anticancer drugs and tumor necrosis factor-alpha 
      (TNF-alpha). Pharmacological inhibition of NF-kappaB offers the promise of 
      enhancing the efficacy of anticancer therapies. Here, we demonstrate that 
      dehydrocostus lactone (DL), the major sesquiterpene lactone isolated from the 
      roots of Saussurea lappa, inhibits NF-kappaB activation by preventing 
      TNF-alpha-induced degradation and phosphorylation of its inhibitory protein 
      I-kappaB alpha in human leukemia HL-60 cells and that DL renders HL-60 cells 
      susceptible to TNF-alpha-induced apoptosis by enhancing caspase-8 and caspase-3 
      activities.
FAU - Oh, G S
AU  - Oh GS
AD  - Department of Microbiology and Immunology, School of Medicine, Wonkwang 
      University, Iksan, Chonbuk, South Korea.
FAU - Pae, H O
AU  - Pae HO
FAU - Chung, H T
AU  - Chung HT
FAU - Kwon, J W
AU  - Kwon JW
FAU - Lee, J H
AU  - Lee JH
FAU - Kwon, T O
AU  - Kwon TO
FAU - Kwon, S Y
AU  - Kwon SY
FAU - Chon, B H
AU  - Chon BH
FAU - Yun, Young Gab
AU  - Yun YG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Lactones)
RN  - 0 (NF-kappa B)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Sesquiterpenes)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 477-43-0 (dehydrocostus lactone)
RN  - EC 3.4.22.- (CASP3 protein, human)
RN  - EC 3.4.22.- (CASP8 protein, human)
RN  - EC 3.4.22.- (Caspase 3)
RN  - EC 3.4.22.- (Caspase 8)
RN  - EC 3.4.22.- (Caspases)
SB  - IM
MH  - Antineoplastic Agents/administration & dosage/isolation & purification
MH  - Apoptosis/*drug effects
MH  - Caspase 3
MH  - Caspase 8
MH  - Caspases/metabolism
MH  - Drug Synergism
MH  - HL-60 Cells
MH  - Humans
MH  - Lactones/*administration & dosage/isolation & purification
MH  - NF-kappa B/metabolism
MH  - Neoplasm Proteins/biosynthesis
MH  - Phytotherapy
MH  - Saussurea/chemistry
MH  - Sesquiterpenes/*administration & dosage/isolation & purification
MH  - Tumor Necrosis Factor-alpha/*administration & dosage
EDAT- 2004/06/24 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/06/24 05:00
PHST- 2004/06/24 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/06/24 05:00 [entrez]
AID - 10.1081/iph-120037712 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 2004 May;26(2):163-75. doi: 10.1081/iph-120037712.