PMID- 15209365
OWN - NLM
STAT- MEDLINE
DCOM- 20041215
LR  - 20191108
IS  - 0892-3973 (Print)
IS  - 0892-3973 (Linking)
VI  - 26
IP  - 2
DP  - 2004 May
TI  - Inhibition of mast cell-dependent allergy reaction by extract of black cohosh 
      (Cimicifuga racemosa).
PG  - 299-308
AB  - Black cohosh (Cimicifuga racemosa) has been used as therapeutics for pain and 
      inflammation in Korean folk medicine. The potential effects of black cohosh 
      extract (BCE) on mast cell-dependent allergy reaction, however, have not been 
      well elucidated yet. In the present study, we investigated the effect of BCE on 
      the allergy reaction using mast cell-dependent in vivo and in vitro models. BCE 
      showed no potential of skin sensitization in local lymph node assay (LLNA). The 
      oral administration of BCE significantly inhibited the anti-IgE-induced passive 
      cutaneous anaphylaxis (PCA) reaction. BCE also showed inhibitory potential on the 
      compound 48/80-induced histamine release from rat peritoneal mast cells. In 
      addition, BCE inhibited the IL-4, IL-5 and TNF-alpha mRNA induction by PMA and 
      A23187 in human leukemia mast cells, HMC-1. These results demonstrated that BCE 
      has an anti-allergic potential and it may be due to the inhibition of histamine 
      release and cytokine gene expression in the mast cells.
FAU - Kim, Chang Deok
AU  - Kim CD
AD  - Oriental Hospital, Oriental Medical College of Daejeon University, Daejeon, South 
      Korea.
FAU - Lee, Won-Kyung
AU  - Lee WK
FAU - Lee, Min-Ho
AU  - Lee MH
FAU - Cho, Ho Song
AU  - Cho HS
FAU - Lee, Yong Koo
AU  - Lee YK
FAU - Roh, Seok-Seon
AU  - Roh SS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Immunopharmacol Immunotoxicol
JT  - Immunopharmacology and immunotoxicology
JID - 8800150
RN  - 0 (Interleukin-5)
RN  - 0 (Plant Extracts)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 207137-56-2 (Interleukin-4)
RN  - 37H9VM9WZL (Calcimycin)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - NI40JAQ945 (Tetradecanoylphorbol Acetate)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Calcimycin/pharmacology
MH  - Cell Line
MH  - *Cimicifuga
MH  - Histamine Release/drug effects
MH  - Humans
MH  - In Vitro Techniques
MH  - Interleukin-4/genetics
MH  - Interleukin-5/genetics
MH  - Male
MH  - Mast Cells/*drug effects/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Passive Cutaneous Anaphylaxis/*drug effects/immunology
MH  - *Phytotherapy
MH  - Plant Extracts/pharmacology
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tetradecanoylphorbol Acetate/pharmacology
MH  - Tumor Necrosis Factor-alpha/genetics
MH  - p-Methoxy-N-methylphenethylamine/toxicity
EDAT- 2004/06/24 05:00
MHDA- 2004/12/16 09:00
CRDT- 2004/06/24 05:00
PHST- 2004/06/24 05:00 [pubmed]
PHST- 2004/12/16 09:00 [medline]
PHST- 2004/06/24 05:00 [entrez]
AID - 10.1081/iph-120037728 [doi]
PST - ppublish
SO  - Immunopharmacol Immunotoxicol. 2004 May;26(2):299-308. doi: 
      10.1081/iph-120037728.