PMID- 15209809
OWN - NLM
STAT- MEDLINE
DCOM- 20041007
LR  - 20151119
IS  - 0105-1873 (Print)
IS  - 0105-1873 (Linking)
VI  - 50
IP  - 5
DP  - 2004 May
TI  - A chemical dataset for evaluation of alternative approaches to skin-sensitization 
      testing.
PG  - 274-88
AB  - Allergic contact dermatitis resulting from skin sensitization is a common 
      occupational and environmental health problem. In recent years, the local lymph 
      node assay (LLNA) has emerged as a practical option for assessing the 
      skin-sensitization potential of chemicals. In addition to accurate identification 
      of skin sensitizers, the LLNA can also provide a reliable measure of relative 
      sensitization potency, information that is pivotal in successful management of 
      human health risks. However, even with the significant animal welfare benefits 
      provided by the LLNA, there is interest still in the development of non-animal 
      test methods for skin sensitization. Here, we provide a dataset of chemicals that 
      have been tested in the LLNA and the activity of which correspond with what is 
      known of their potential to cause skin sensitization in humans. It is anticipated 
      that this will be of value to other investigators in the evaluation and 
      calibration of novel approaches to skin-sensitization testing. The materials that 
      comprise this dataset encompass both the chemical and biological diversity of 
      known chemical allergens and provide also examples of negative controls. It is 
      hoped that this dataset will accelerate the development, evaluation and eventual 
      validation of new approaches to skin-sensitization testing.
FAU - Gerberick, G Frank
AU  - Gerberick GF
AD  - The Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, OH 
      45253-8707, USA. gerberick.gf@pg.com
FAU - Ryan, Cindy A
AU  - Ryan CA
FAU - Kern, Petra S
AU  - Kern PS
FAU - Dearman, Rebecca J
AU  - Dearman RJ
FAU - Kimber, Ian
AU  - Kimber I
FAU - Patlewicz, Grace Y
AU  - Patlewicz GY
FAU - Basketter, David A
AU  - Basketter DA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Contact Dermatitis
JT  - Contact dermatitis
JID - 7604950
RN  - 0 (Allergens)
SB  - IM
MH  - *Allergens
MH  - Dermatitis, Allergic Contact/*diagnosis/pathology
MH  - Humans
MH  - *Local Lymph Node Assay
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
EDAT- 2004/06/24 05:00
MHDA- 2004/10/08 09:00
CRDT- 2004/06/24 05:00
PHST- 2004/06/24 05:00 [pubmed]
PHST- 2004/10/08 09:00 [medline]
PHST- 2004/06/24 05:00 [entrez]
AID - COD290 [pii]
AID - 10.1111/j.0105-1873.2004.00290.x [doi]
PST - ppublish
SO  - Contact Dermatitis. 2004 May;50(5):274-88. doi: 10.1111/j.0105-1873.2004.00290.x.