PMID- 15209954
OWN - NLM
STAT- MEDLINE
DCOM- 20041001
LR  - 20220408
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 15
IP  - 3
DP  - 2004 Jun
TI  - Natural history of atopic dermatitis and its relationship to serum total 
      immunoglobulin E in a population-based birth cohort study.
PG  - 221-9
AB  - We investigated the natural history of atopic dermatitis (AD) in a 
      population-based birth cohort and assessed whether children at risk of visible 
      eczema at 5 years of age can be identified from total immunoglobulin E (IgE) 
      levels measured at 8, 12 and 18 months. AD data collected included a whole body 
      examination for visible eczema at 49 months (4 years) and 61 months (5 years) of 
      age and parent completed questionnaire data throughout their early lives. 
      Children were divided into four groups based on their natural history of early 
      AD: persistent (AD at 1, 6, 18, 30 and 42 months, n = 34), intermittent early 
      onset (before 18 months of age, n = 495), intermittent late onset (18-42 months 
      of age, n = 273) and unaffected (n = 429). Visible eczema at 5 years of age was 
      present in 12.2% (117/957) (95% confidence interval [CI] 10.1-14.3%) of the 
      children. Levels of total IgE at 8, 12 and 18 months of age were associated with 
      early onset of AD, but not with AD of later onset. For all four natural history 
      groups, the geometric mean total IgE at 12 months was higher in those who 
      subsequently had visible eczema than those who did not. However, the degree of 
      overlap was such that total IgE at 12 months of age was a poor predictor of 
      eczema at age five. A cutoff point of 78 kU/l had the highest positive predictive 
      value for visible eczema at 5 years of age of 28.6%, with a sensitivity of 12% 
      and specificity of 95%.
CI  - Copyright 2004 Blackwell Munksgaard
FAU - Perkin, Michael R
AU  - Perkin MR
AD  - Department of Child Health, St George's Hospital Medical School, London, UK. 
      m.perkin@sghms.ac.uk
FAU - Strachan, David P
AU  - Strachan DP
FAU - Williams, Hywel C
AU  - Williams HC
FAU - Kennedy, Cameron T C
AU  - Kennedy CT
FAU - Golding, Jean
AU  - Golding J
CN  - ALSPAC Study Team
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Age Factors
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Dermatitis, Atopic/epidemiology/etiology/*immunology
MH  - Eczema/immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Predictive Value of Tests
MH  - Prevalence
MH  - ROC Curve
MH  - Regression Analysis
MH  - Skin Tests
MH  - Surveys and Questionnaires
EDAT- 2004/06/24 05:00
MHDA- 2004/10/02 05:00
CRDT- 2004/06/24 05:00
PHST- 2004/06/24 05:00 [pubmed]
PHST- 2004/10/02 05:00 [medline]
PHST- 2004/06/24 05:00 [entrez]
AID - PAI160 [pii]
AID - 10.1111/j.1399-3038.2004.00160.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2004 Jun;15(3):221-9. doi: 
      10.1111/j.1399-3038.2004.00160.x.