PMID- 15209961
OWN - NLM
STAT- MEDLINE
DCOM- 20041001
LR  - 20131121
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 15
IP  - 3
DP  - 2004 Jun
TI  - Serum leptin level in children with atopic dermatitis-treated topical steroids.
PG  - 267-9
AB  - Leptin, the obese gene product, is a 16-kDa peptide hormone secreted by 
      adiposities. Systemic administration of exogenous glucocorticoids has been found 
      to increase circulating leptin levels. In this study, we aimed to assess serum 
      leptin in children with atopic dermatitis (AD)-treated with local steroids. 
      Twenty children with AD were included during the 2001-2002 time period. The study 
      was conducted prospectively. Atopy was defined as the presence of at least one 
      aeroallergen-specific immunoglobulin E (IgE) antibody. Serum leptin was 
      determined using a commercially available radioimmunoassay kit with 3.4-8.3% 
      intra-assay and 3.0-6.2% interassay coefficients of variation, and 0.5 ng/ml 
      sensitivity. Fourteen boys and six girls with AD, the mean age of the patients 
      was 3.1 +/- 2.2. Forty-three percentage of the family histories for atopy were 
      positive, 60% of the cases passive smoking histories were positive. In seven 
      patients the aeroallergen-specific IgE were positive. All 20 patients treated 
      clobetasone 17-butirate (0.05%). There was no significant difference in serum 
      leptin between patients (mean +/- s.d.: 4.6 +/- 3.8), and controls (mean +/- 
      s.d.: 6.2 +/- 3.6) (p > 0.05). Local steroid does not influence circulating 
      leptin levels, suggesting that regulation of body weight is unaffected.
CI  - Copyright 2004 Blackwell Munksgaard
FAU - Bostanci, Ilknur
AU  - Bostanci I
AD  - Department of Pediatric Allergy, Ankara Education and Research Hospital, Ankara, 
      Turkey. ilknurbirol@hotmail.com
FAU - Atli, Ozlem
AU  - Atli O
FAU - Celebi, Nermin
AU  - Celebi N
FAU - Tasar, Aysin
AU  - Tasar A
FAU - Alpkarakoc, Esra
AU  - Alpkarakoc E
FAU - Dallar, Yildiz
AU  - Dallar Y
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Glucocorticoids)
RN  - 0 (Leptin)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 8U0H6XI6EO (clobetasone butyrate)
RN  - ADN79D536H (Clobetasol)
SB  - IM
MH  - Administration, Topical
MH  - Case-Control Studies
MH  - Child
MH  - Child, Preschool
MH  - Clobetasol/*analogs & derivatives/*therapeutic use
MH  - Dermatitis, Atopic/blood/*drug therapy
MH  - Female
MH  - Glucocorticoids/*therapeutic use
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Leptin/*blood
MH  - Male
MH  - Prospective Studies
EDAT- 2004/06/24 05:00
MHDA- 2004/10/02 05:00
CRDT- 2004/06/24 05:00
PHST- 2004/06/24 05:00 [pubmed]
PHST- 2004/10/02 05:00 [medline]
PHST- 2004/06/24 05:00 [entrez]
AID - PAI145 [pii]
AID - 10.1111/j.1399-3038.2004.00145.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2004 Jun;15(3):267-9. doi: 
      10.1111/j.1399-3038.2004.00145.x.