PMID- 15212113
OWN - NLM
STAT- MEDLINE
DCOM- 20040805
LR  - 20131121
IS  - 0393-5264 (Print)
IS  - 0393-5264 (Linking)
VI  - 19
IP  - 1
DP  - 2004 Jan-Mar
TI  - Personality and the effects of acute alcohol intake. A contingent negative 
      variation study in healthy subjects.
PG  - 25-30
AB  - This study investigates the relationship between blood alcohol concentrations 
      (BACs) and contingent negative variation (CNV). Fourteen healthy subjects were 
      divided on the basis of their personality profiles--the Minnesota Multiphasic 
      Personality Inventory (Hs+Hy+D/3)--into a high score (HS) and low score (LS) 
      subgroup. The CNV was recorded using a choice-reaction time (RT) task. CNV 
      recording was performed in two conditions: inter-stimulus intervals (ISIs) of 
      1500 ms and 2500 ms at three different BACs (0.3, 0.5 and 0.8 g/L) after acute 
      alcohol administration. At the high BAC (0.8 g/L), both subgroups showed a 
      reduced CNV amplitude area and a longer RT (p<.05) in both ISI conditions. No 
      effects either on the CNV or on the RT were observed at the low BAC (0.3 g/L). At 
      the intermediate BAC (0.5 g/L), the HS subgroup displayed an increased CNV 
      amplitude (p<.05), not accompanied by a significantly longer RT (short ISI 
      condition), and a reduced late CNV (p<.05) with a longer RT (p<.05) (long ISI 
      condition). In the LS group, only a longer RT was observed in the long ISI 
      condition. CNV modifications point to an individual, apparently 
      personality-related, threshold of sensitivity to different alcohol levels.
FAU - Fattapposta, Francesco
AU  - Fattapposta F
AD  - Department of Neurology and Otolaryngology, University La Sapienza, Rome, Italy. 
      francesco.fattapposta@uniroma1.it
FAU - Venturi, Piero
AU  - Venturi P
FAU - Carella Prada, Ozrem
AU  - Carella Prada O
FAU - Costamagna, Luisa
AU  - Costamagna L
FAU - D'Alessio, Carmelo
AU  - D'Alessio C
FAU - Mostarda, Mirella
AU  - Mostarda M
FAU - Mina, Concetta
AU  - Mina C
FAU - Parisi, Leoluca
AU  - Parisi L
FAU - Pirro, Cristina
AU  - Pirro C
FAU - Amabile, Giuseppe
AU  - Amabile G
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Italy
TA  - Funct Neurol
JT  - Functional neurology
JID - 8707746
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Adult
MH  - Alcoholic Intoxication/*blood/psychology
MH  - Analysis of Variance
MH  - Choice Behavior/drug effects/physiology
MH  - Contingent Negative Variation/*drug effects/physiology
MH  - Differential Threshold
MH  - Dose-Response Relationship, Drug
MH  - Ethanol/*blood
MH  - Female
MH  - Humans
MH  - MMPI
MH  - Male
MH  - Personality/*physiology
MH  - Problem Solving/*drug effects/physiology
MH  - Reaction Time/*drug effects/physiology
MH  - Reference Values
MH  - Time Factors
EDAT- 2004/06/24 05:00
MHDA- 2004/08/06 05:00
CRDT- 2004/06/24 05:00
PHST- 2004/06/24 05:00 [pubmed]
PHST- 2004/08/06 05:00 [medline]
PHST- 2004/06/24 05:00 [entrez]
PST - ppublish
SO  - Funct Neurol. 2004 Jan-Mar;19(1):25-30.