PMID- 15212460
OWN - NLM
STAT- MEDLINE
DCOM- 20040803
LR  - 20180816
IS  - 0021-8561 (Print)
IS  - 0021-8561 (Linking)
VI  - 52
IP  - 13
DP  - 2004 Jun 30
TI  - Synergistic effect of antioxidant phenolic acids on human phenolsulfotransferase 
      activity.
PG  - 4139-43
AB  - Sulfate conjugation by phenolsulfotransferases (PSTs) is an important process in 
      the detoxification of xenobiotics and endogenous compounds. There are two forms 
      of PSTs for the sulfation of small phenols (PST-P) and monoamines (PST-M). 
      Phenolic acids are known to increase the activities of PST-P and PST-M. The 
      purpose of this study is to investigate the synergistic effect of the 
      combinations of phenolic acids on human PSTs activities. The combinations of 
      p-hydroxybenzoic acid, gentisic acid, ferulic acid, gallic acid, and coumaric 
      acid in a random order for their effects on PSTs activities were evaluated at 
      concentrations of 2.5, 5.0, and 7.5 microM. The PST-M activity was significantly 
      increased when gentisic acid was combined with each of the other phenolic acids. 
      When p-hydroxybenzoic acid was combined with each of the other phenolic acids, a 
      synergistic effect with respect to the promotion of PST-P activity was obtained. 
      A potential synergistic effect for the PST-P activity was also found in the 
      following combination: p-hydroxybenzoic acid + gallic acid + gentisic acid, 
      p-hydroxybenzoic acid + gallic acid + m-coumaric acid, p-hydroxybenzoic acid + 
      o-coumaric acid + p-coumaric acid, p-hydroxybenzoic acid + o-coumaric acid + 
      m-coumaric acid, gallic acid + gentisic acid + p-coumaric acid, and gallic acid + 
      o-coumaric acid + m-coumaric acid. Therefore, the activities of both forms of 
      PSTs can be promoted by all of these combinations of phenolic acids. These 
      results provide a better understanding regarding the effect of phenolic acids on 
      human PSTs activities, as well as more information on the intake of antioxidant 
      phenolic acids for human health.
FAU - Yeh, Chi-Tai
AU  - Yeh CT
AD  - Department of Food Science, National Chung-Hsing University, 250 Kuokuang Road, 
      Taichung 40227, Taiwan.
FAU - Shih, Ping-Hsiao
AU  - Shih PH
FAU - Yen, Gow-Chin
AU  - Yen GC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Antioxidants)
RN  - 0 (Coumaric Acids)
RN  - 0 (Gentisates)
RN  - 0 (Hydroxybenzoates)
RN  - 632XD903SP (Gallic Acid)
RN  - AVM951ZWST (ferulic acid)
RN  - EC 2.8.2.1 (Arylsulfotransferase)
RN  - I3P9R8317T (phenolic acid)
RN  - VP36V95O3T (2,5-dihydroxybenzoic acid)
SB  - IM
MH  - Antioxidants/*pharmacology
MH  - Arylsulfotransferase/*metabolism
MH  - Coumaric Acids/pharmacology
MH  - Drug Synergism
MH  - Gallic Acid/pharmacology
MH  - Gentisates/pharmacology
MH  - Humans
MH  - Hydroxybenzoates/*pharmacology
EDAT- 2004/06/24 05:00
MHDA- 2004/08/04 05:00
CRDT- 2004/06/24 05:00
PHST- 2004/06/24 05:00 [pubmed]
PHST- 2004/08/04 05:00 [medline]
PHST- 2004/06/24 05:00 [entrez]
AID - 10.1021/jf035339u [doi]
PST - ppublish
SO  - J Agric Food Chem. 2004 Jun 30;52(13):4139-43. doi: 10.1021/jf035339u.